Vascular Grafts with Tailored Stiffness and a Ligand Environment via Multiarmed Polymer Sheath for Expeditious Regeneration.
Animals
Cell Adhesion
/ drug effects
Cell Differentiation
/ drug effects
Cell Proliferation
/ drug effects
Elastic Modulus
Humans
Ligands
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
/ cytology
Myocytes, Smooth Muscle
/ cytology
Norbornanes
/ chemistry
Oligopeptides
/ chemistry
Peptides
/ chemistry
Polyesters
/ chemistry
Polyethylene Glycols
/ chemistry
Polymers
/ chemistry
Rats
Rats, Sprague-Dawley
Regeneration
/ drug effects
Transforming Growth Factor beta1
/ chemistry
coaxial electrospun fiber
multi-armed polymer
polyethylene glycol-norbornene
regeneration
stiffness
vascular graft
Journal
ACS applied bio materials
ISSN: 2576-6422
Titre abrégé: ACS Appl Bio Mater
Pays: United States
ID NLM: 101729147
Informations de publication
Date de publication:
18 01 2021
18 01 2021
Historique:
entrez:
30
8
2021
pubmed:
31
8
2021
medline:
31
8
2021
Statut:
ppublish
Résumé
The bypass graft is the mainstream of surgical intervention to treat vascular diseases. Ideal bypass materials, yet to be developed, require mechanical properties, availability, clinically feasible manufacturing logistics, and bioactivities with precise physicochemical cues defined to guide cell activities for arterial regeneration. Such needs instigated our fabrication of vascular grafts, which consist of coaxial, nanostructured fibers exhibiting a polycaprolactone (PCL) core and a photoclickable, 4-arm thiolated polyethylene glycol-norbornene (PEG-NB) sheath. The graft strength and bioactivity were modulated by the PCL concentration and the peptides (RGD, transforming growth factor
Identifiants
pubmed: 34458689
doi: 10.1021/acsabm.0c01114
pmc: PMC8386521
mid: NIHMS1711049
doi:
Substances chimiques
Ligands
0
Norbornanes
0
Oligopeptides
0
Peptides
0
Polyesters
0
Polymers
0
Transforming Growth Factor beta1
0
polycaprolactone
24980-41-4
2-norbornene
2Q51FLS550
Polyethylene Glycols
3WJQ0SDW1A
arginyl-glycyl-aspartic acid
78VO7F77PN
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Pagination
545-558Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL119371
Pays : United States
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