Synthesis and structure-activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: high affinity and selective somatostatin receptor-4 agonists for Alzheimer's disease treatment.


Journal

RSC medicinal chemistry
ISSN: 2632-8682
Titre abrégé: RSC Med Chem
Pays: England
ID NLM: 101759460

Informations de publication

Date de publication:
18 Aug 2021
Historique:
received: 11 02 2021
accepted: 14 04 2021
entrez: 30 8 2021
pubmed: 31 8 2021
medline: 31 8 2021
Statut: epublish

Résumé

Somatostatin receptor-4 (SST

Identifiants

pubmed: 34458738
doi: 10.1039/d1md00044f
pii: d1md00044f
pmc: PMC8372316
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1352-1365

Subventions

Organisme : NIA NIH HHS
ID : R01 AG047858
Pays : United States

Informations de copyright

This journal is © The Royal Society of Chemistry.

Déclaration de conflit d'intérêts

The authors declared the following conflict of interests: Drs. Neumann, Sandoval, Kontoyianni, Hospital, Crider, and Witt are co-inventors on patent applications for the development of SST4 agonists, through Southern Illinois University Edwardsville (USA patent application No. PCT/US2018/032368; European National Application No. 18798793.8, Japanese Application No. 2019-562574). Ken Witt is CEO of Somatolynk Inc., a company focused on advancement of SST4 agonists.

Références

Arch Int Pharmacodyn Ther. 1990 May-Jun;305:140-51
pubmed: 2241425
Front Neural Circuits. 2016 Jun 30;10:48
pubmed: 27445703
Front Neuroendocrinol. 1999 Jul;20(3):157-98
pubmed: 10433861
Nature. 1980 Nov 20;288(5788):279-80
pubmed: 6107862
Mol Cell Endocrinol. 2008 May 14;286(1-2):75-87
pubmed: 17997029
Nature. 2012 Dec 13;492(7428):215-20
pubmed: 23235874
DNA Cell Biol. 1995 Nov;14(11):939-44
pubmed: 7576180
Biochim Biophys Acta. 2003 Sep 22;1616(1):1-84
pubmed: 14507421
Neuroscience. 2000;98(3):523-33
pubmed: 10869846
Eur J Pharmacol. 2012 May 15;683(1-3):116-24
pubmed: 22449380
J Physiol. 2006 Apr 15;572(Pt 2):477-92
pubmed: 16469784
J Neurosci. 2000 May 15;20(10):3785-97
pubmed: 10804219
Chem Res Toxicol. 1997 Jul;10(7):733-41
pubmed: 9250406
Neurosci Lett. 2003 Oct 23;350(2):113-6
pubmed: 12972166
J Med Chem. 2010 Jul 22;53(14):5061-84
pubmed: 20345171
J Med Chem. 1998 Nov 19;41(24):4693-705
pubmed: 9822540
Neuropeptides. 1983 Apr;3(4):263-70
pubmed: 6135174
Brain Res. 1987 Feb 17;403(2):234-42
pubmed: 3828820
Nat Med. 2005 Apr;11(4):434-9
pubmed: 15778722
J Chem Inf Model. 2012 Jan 23;52(1):171-86
pubmed: 22148589
Neurochem Res. 2009 Apr;34(4):660-9
pubmed: 19247832
Science. 2019 Aug 9;365(6453):559-565
pubmed: 31395777
Brain Res. 2013 Jul 3;1520:145-56
pubmed: 23669069
J Med Chem. 2003 Jun 5;46(12):2334-44
pubmed: 12773038
J Alzheimers Dis. 2019;68(4):1699-1710
pubmed: 30958364
Neuropeptides. 1988 Nov-Dec;12(4):237-42
pubmed: 2907122
Front Endocrinol (Lausanne). 2018 Feb 27;9:55
pubmed: 29535682
EMBO Mol Med. 2016 Jun 01;8(6):595-608
pubmed: 27025652
Eur J Pharmacol. 2006 Jun 6;539(1-2):71-5
pubmed: 16697366
Medchemcomm. 2018 Nov 7;9(12):2083-2090
pubmed: 30746066
Neurobiol Dis. 2006 Dec;24(3):475-83
pubmed: 17008108
Brain Res Bull. 2018 Jul;141:20-26
pubmed: 29174732
Behav Brain Res. 2008 Sep 1;192(1):106-13
pubmed: 18359102
Eur J Pharmacol. 2011 Mar 1;654(1):53-9
pubmed: 21185826
Nitric Oxide. 2017 May 1;65:10-21
pubmed: 28137611
Mol Cell Endocrinol. 2008 May 14;286(1-2):96-103
pubmed: 18221832
Prog Neurobiol. 2009 Oct;89(2):153-61
pubmed: 19595735
J Alzheimers Dis. 2017;59(3):913-927
pubmed: 28697571
Nature. 2006 Mar 16;440(7082):352-7
pubmed: 16541076
Neuroscience. 2017 Mar 27;346:320-336
pubmed: 28161436
Psychopharmacology (Berl). 2009 Jan;202(1-3):153-63
pubmed: 18521573
Int J Mol Sci. 2019 Jun 17;20(12):
pubmed: 31212931
J Neurosci. 2008 Apr 2;28(14):3567-76
pubmed: 18385315
Brain Res. 2007 Jun 4;1152:191-200
pubmed: 17459354
Proc Natl Acad Sci U S A. 1980 Jul;77(7):3947-51
pubmed: 6254004
Curr Pharm Des. 2012;18(8):1123-30
pubmed: 22288401
J Neurosci. 2016 Sep 14;36(37):9647-58
pubmed: 27629715
Neuropharmacology. 2016 Feb;101:204-15
pubmed: 26387439
Pharmacol Ther. 2005 Nov;108(2):129-48
pubmed: 16112736
J Physiol Paris. 2000 May-Aug;94(3-4):211-5
pubmed: 11087999
Neurobiol Aging. 2019 Apr;76:18-23
pubmed: 30616208
J Biol Chem. 2006 Jun 30;281(26):17941-51
pubmed: 16636059
Physiol Behav. 2002 Aug;76(4-5):531-8
pubmed: 12126989
Neurochem Res. 2019 Nov;44(11):2670-2680
pubmed: 31630317
Nat Rev Drug Discov. 2017 Dec;16(12):829-842
pubmed: 29075003
J Drug Target. 1998;6(2):151-65
pubmed: 9886238
Eur J Pharmacol. 1988 Jul 14;151(3):399-407
pubmed: 2905659
J Neurochem. 2012 Jan;120 Suppl 1:125-139
pubmed: 22121920
Pharmacol Rev. 2018 Oct;70(4):763-835
pubmed: 30232095
J Alzheimers Dis. 2016 Oct 18;54(4):1339-1348
pubmed: 27589526
Neuropsychopharmacology. 2017 Jul;42(8):1647-1656
pubmed: 27986975
Rev Neurosci. 2003;14(3):285-301
pubmed: 14513869
Front Endocrinol (Lausanne). 2012 Dec 06;3:154
pubmed: 23230430
Brain Res. 2000 Jul 28;872(1-2):242-9
pubmed: 10924702

Auteurs

William L Neumann (WL)

Department of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.

Karin E Sandoval (KE)

Department of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.

Shirin Mobayen (S)

Department of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.

Mahsa Minaeian (M)

Department of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.

Stephen G Kukielski (SG)

Department of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.

Khush N Srabony (KN)

Department of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.

Rafael Frare (R)

Department of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.

Olivia Slater (O)

Department of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.

Susan A Farr (SA)

Research and Development Service, VA Medical Center, Division of Geriatric Medicine, Saint Louis University School of Medicine 1402 South Grand Boulevard, M238 St Louis MO 63104 USA.

Michael L Niehoff (ML)

Research and Development Service, VA Medical Center, Division of Geriatric Medicine, Saint Louis University School of Medicine 1402 South Grand Boulevard, M238 St Louis MO 63104 USA.

Audrey Hospital (A)

Department of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.

Maria Kontoyianni (M)

Department of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.

A Michael Crider (AM)

Department of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.

Ken A Witt (KA)

Department of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.

Classifications MeSH