Crosslinker-modified nucleic acid probes for improved target identification and biomarker detection.
Journal
RSC chemical biology
ISSN: 2633-0679
Titre abrégé: RSC Chem Biol
Pays: England
ID NLM: 101768727
Informations de publication
Date de publication:
01 Apr 2021
01 Apr 2021
Historique:
received:
22
12
2020
accepted:
11
02
2021
entrez:
30
8
2021
pubmed:
31
8
2021
medline:
31
8
2021
Statut:
epublish
Résumé
Understanding the intricate interaction pattern of nucleic acids with other molecules is essential to gain further insight in biological processes and disease mechanisms. To this end, a multitude of hybridization-based assays have been designed that rely on the non-covalent recognition between complementary nucleic acid sequences. However, the ephemeral nature of these interactions complicates straightforward analysis as low efficiency and specificity are rule rather than exception. By covalently locking nucleic acid interactions by means of a crosslinking agent, the overall efficiency, specificity and selectivity of hybridization-based assays could be increased. In this mini-review we highlight methodologies that exploit the use of crosslinker-modified nucleic acid probes for interstrand nucleic acid crosslinking with the objective to study, detect and identify important targets as well as nucleic acid sequences that can be considered relevant biomarkers. We emphasize on the usefulness and advantages of crosslinking agents and elaborate on the chemistry behind the crosslinking reactions they induce.
Identifiants
pubmed: 34458792
doi: 10.1039/d0cb00236d
pii: d0cb00236d
pmc: PMC8341421
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
410-422Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
There are no conflicts to declare.
Références
J Org Chem. 2014 Mar 21;79(6):2463-72
pubmed: 24571436
Chembiochem. 2017 Jul 18;18(14):1383-1386
pubmed: 28422400
Bioorg Med Chem. 2009 Jan 15;17(2):475-83
pubmed: 19135379
Bioorg Med Chem Lett. 2018 Sep 15;28(17):2906-2909
pubmed: 30021704
Chembiochem. 2016 Nov 3;17(21):2046-2053
pubmed: 27558701
Mol Cell. 2008 May 23;30(4):460-71
pubmed: 18498749
Chem Commun (Camb). 2016 May 10;52(40):6720-2
pubmed: 27117176
Chembiochem. 2009 Jan 5;10(1):109-18
pubmed: 19012292
Chembiochem. 2018 Dec 18;19(24):2550-2552
pubmed: 30341988
Angew Chem Int Ed Engl. 2020 Dec 1;59(49):22017-22022
pubmed: 32845055
Adv Exp Med Biol. 2016;937:53-69
pubmed: 27573894
J Am Chem Soc. 2008 Nov 5;130(44):14398-9
pubmed: 18842048
Nature. 2013 Jan 10;493(7431):231-5
pubmed: 23201690
Clin Exp Med. 2020 Aug;20(3):349-359
pubmed: 32399814
Bioorg Med Chem. 2012 Jan 15;20(2):554-70
pubmed: 21778062
J Nutr Biochem. 2010 Aug;21(8):665-70
pubmed: 20303730
J Am Chem Soc. 2006 Jan 18;128(2):485-91
pubmed: 16402835
Angew Chem Int Ed Engl. 2014 Jul 1;53(27):7001-5
pubmed: 24840115
J Am Chem Soc. 2014 Mar 5;136(9):3483-90
pubmed: 24506784
Chem Commun (Camb). 2016 Jan 28;52(8):1539-54
pubmed: 26679922
Org Biomol Chem. 2019 Jun 26;17(25):6277-6283
pubmed: 31192345
Nat Rev Cancer. 2011 Jun;11(6):426-37
pubmed: 21562580
Org Biomol Chem. 2018 Feb 7;16(6):891-894
pubmed: 29340411
Biochemistry. 2000 Jul 25;39(29):8683-91
pubmed: 10913277
Nature. 1970 Aug 8;227(5258):561-3
pubmed: 4913914
Exp Biol Med (Maywood). 2017 Jan;242(2):184-193
pubmed: 27633578
Front Microbiol. 2020 Jun 03;11:1197
pubmed: 32582115
Molecules. 2017 Nov 20;22(11):
pubmed: 29156637
J Am Chem Soc. 2012 Jul 4;134(26):10737-40
pubmed: 22698383
J Mol Diagn. 2005 May;7(2):258-67
pubmed: 15858150
J Photochem Photobiol B. 1998 Feb;42(2):109-24
pubmed: 9540218
Chem Sci. 2020 Oct 9;11(43):11729-11739
pubmed: 34094412
Chem Commun (Camb). 2005 Feb 21;(7):936-8
pubmed: 15700087
J Am Chem Soc. 2011 Feb 2;133(4):796-807
pubmed: 21162525
Clin Chem. 2002 Oct;48(10):1844-50
pubmed: 12324515
Chem Asian J. 2019 Jun 3;14(11):1912-1916
pubmed: 30806028
Angew Chem Int Ed Engl. 2012 Jun 11;51(24):5880-3
pubmed: 22566243
Nucleosides Nucleotides Nucleic Acids. 2007;26(3):277-90
pubmed: 17454737
RSC Adv. 2019 Oct 15;9(56):32804-32810
pubmed: 35529740
Photochem Photobiol. 2014 May-Jun;90(3):716-22
pubmed: 24372306
Bioconjug Chem. 2006 Nov-Dec;17(6):1561-7
pubmed: 17105237
Biomed Res Int. 2019 Mar 19;2019:9056458
pubmed: 31016202
J Am Chem Soc. 2008 Aug 6;130(31):10299-306
pubmed: 18620398
RNA. 2018 Apr;24(4):597-608
pubmed: 29246928
Methods Mol Biol. 2016;1480:115-23
pubmed: 27659979
ACS Chem Biol. 2017 Aug 18;12(8):2191-2200
pubmed: 28714670
Biochemistry. 1988 Dec 27;27(26):9113-21
pubmed: 2468360
J Am Chem Soc. 2013 Oct 30;135(43):16161-7
pubmed: 24087918
J Am Chem Soc. 2007 Feb 21;129(7):1852-3
pubmed: 17253689
Photochem Photobiol. 1979 Jun;29(6):1177-97
pubmed: 388473
Cancer Med. 2012 Oct;1(2):237-60
pubmed: 23342273
J Org Chem. 2014 Dec 5;79(23):11359-69
pubmed: 25372021
Chembiochem. 2008 Dec 15;9(18):2981-8
pubmed: 19035374
Mol Cell. 2018 Feb 1;69(3):354-369
pubmed: 29395060
J Pathol. 2020 Apr;250(5):480-495
pubmed: 32100288
Chem Commun (Camb). 2003 Jun 21;(12):1370-1
pubmed: 12841246
Nature. 2007 Feb 8;445(7128):666-70
pubmed: 17237763
Anal Chim Acta. 2020 Jun 8;1115:61-85
pubmed: 32370870
J Microbiol Methods. 2017 Aug;139:22-28
pubmed: 28434824
Acc Chem Res. 2014 Feb 18;47(2):646-55
pubmed: 24369694
ACS Chem Biol. 2016 Aug 19;11(8):2091-100
pubmed: 27267401
Chembiochem. 2006 Dec;7(12):1965-9
pubmed: 17106908
Clin Chem. 1997 Sep;43(9):1703-8
pubmed: 9299963
Eur J Pharm Sci. 2001 Apr;13(1):25-34
pubmed: 11292565
Angew Chem Int Ed Engl. 2014 Dec 8;53(50):13785-8
pubmed: 25314130
Cell. 2010 Apr 2;141(1):129-41
pubmed: 20371350
Dev Cell. 2013 Apr 15;25(1):69-80
pubmed: 23541921
J Am Chem Soc. 2005 Aug 3;127(30):10510-1
pubmed: 16045337
Nucleic Acids Res. 2008 Mar;36(5):e31
pubmed: 18281702
Org Lett. 2018 May 18;20(10):2802-2805
pubmed: 29701982
Mol Neurobiol. 2017 Apr;54(3):2012-2021
pubmed: 26910817
Clin Chem. 2004 Feb;50(2):296-305
pubmed: 14656900
Mol Biol Rep. 1994 Jul;20(1):35-44
pubmed: 7531281
Nat Chem Biol. 2015 Feb;11(2):107-14
pubmed: 25531890
Org Lett. 2008 Aug 7;10(15):3227-30
pubmed: 18582065
Nucleosides Nucleotides Nucleic Acids. 2020;39(1-3):119-130
pubmed: 31645189
Angew Chem Int Ed Engl. 2007;46(42):8020-3
pubmed: 17853519
RSC Adv. 2019 Sep 27;9(53):30693-30697
pubmed: 35529377
Angew Chem Int Ed Engl. 2019 Feb 25;58(9):2680-2684
pubmed: 30694591
Angiology. 1953 Aug;4(4):380-90
pubmed: 13065785
Bioorg Med Chem Lett. 2019 Aug 15;29(16):2173-2177
pubmed: 31257081
Biomater Sci. 2014 Sep 29;2(9):1154-1157
pubmed: 32481888
RNA Biol. 2013 Oct;10(10):1579-85
pubmed: 24036695
Org Lett. 2015 Feb 20;17(4):936-9
pubmed: 25654759
Chem Res Toxicol. 1989 Mar-Apr;2(2):69-75
pubmed: 2519712
J Am Chem Soc. 2013 Jul 3;135(26):9691-9
pubmed: 23745667
Cold Spring Harb Perspect Biol. 2019 Nov 1;11(11):
pubmed: 31676573
J Clin Microbiol. 1999 Jan;37(1):161-4
pubmed: 9854083
Cancer Cell. 2016 Apr 11;29(4):452-463
pubmed: 27070700
Molecules. 2014 May 23;19(5):6891-910
pubmed: 24858274
J Mol Biol. 1982 Nov 25;162(1):157-72
pubmed: 7154093
Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20497-502
pubmed: 22143764
Adv Genet. 2010;70:27-56
pubmed: 20920744