Hyaluronan (HA)-inspired glycopolymers as molecular tools for studying HA functions.
Journal
RSC chemical biology
ISSN: 2633-0679
Titre abrégé: RSC Chem Biol
Pays: England
ID NLM: 101768727
Informations de publication
Date de publication:
01 Apr 2021
01 Apr 2021
Historique:
received:
04
12
2020
accepted:
20
01
2021
entrez:
30
8
2021
pubmed:
31
8
2021
medline:
31
8
2021
Statut:
epublish
Résumé
Hyaluronic acid (HA), the only non-sulphated glycosaminoglycan, serves numerous structural and biological functions in the human body, from providing viscoelasticity in tissues to creating hydrated environments for cell migration and proliferation. HA is also involved in the regulation of morphogenesis, inflammation and tumorigenesis through interactions with specific HA-binding proteins. Whilst the physicochemical and biological properties of HA have been widely studied for decades, the exact mechanisms by which HA exerts its multiple functions are not completely understood. Glycopolymers offer a simple and precise synthetic platform for the preparation of glycan analogues, being an alternative to the demanding synthetic chemical glycosylation. A library of homo, statistical and alternating HA glycopolymers were synthesised by reversible addition-fragmentation chain transfer polymerisation and post-modification utilising copper alkyne-azide cycloaddition to graft orthogonal pendant HA monosaccharides (
Identifiants
pubmed: 34458800
doi: 10.1039/d0cb00223b
pii: d0cb00223b
pmc: PMC8341579
doi:
Types de publication
Journal Article
Langues
eng
Pagination
568-576Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
There are no conflicts to declare.
Références
Angew Chem Int Ed Engl. 2001 Jun 1;40(11):2004-2021
pubmed: 11433435
J Biol Chem. 2000 Jun 30;275(26):20157-67
pubmed: 10779524
Protein Sci. 2007 Jun;16(6):1042-52
pubmed: 17473009
Chem Soc Rev. 2013 May 21;42(10):4476-91
pubmed: 23595539
Angew Chem Int Ed Engl. 2013 Nov 4;52(45):11796-9
pubmed: 24123787
Physiol Rev. 2011 Jan;91(1):221-64
pubmed: 21248167
J Med Chem. 2014 Mar 27;57(6):2714-25
pubmed: 24606063
Nanoscale. 2019 Nov 28;11(44):21155-21166
pubmed: 31663091
Am J Cardiol. 1984 Mar 15;53(7):941-4
pubmed: 6702649
J Am Chem Soc. 2006 Nov 1;128(43):14156-65
pubmed: 17061900
Biochim Biophys Acta. 2002 Sep 19;1572(2-3):364-86
pubmed: 12223280
Curr Opin Immunol. 2013 Feb;25(1):46-52
pubmed: 23332826
Angew Chem Int Ed Engl. 2013 Feb 18;52(8):2335-9
pubmed: 23345258
Cancer Res. 2011 Aug 1;71(15):5317-26
pubmed: 21685475
J Exp Med. 2002 Jan 7;195(1):99-111
pubmed: 11781369
Biomacromolecules. 2018 Jul 9;19(7):3040-3047
pubmed: 29870244
Matrix Biol. 2002 Jan;21(1):31-7
pubmed: 11827790
Acta Biomater. 2014 Apr;10(4):1558-70
pubmed: 24361428
Mar Drugs. 2013 Mar 11;11(3):747-74
pubmed: 23478485
J Am Chem Soc. 2008 Mar 12;130(10):2959-61
pubmed: 18275195
Org Lett. 2002 Oct 17;4(21):3675-8
pubmed: 12375916
Atherosclerosis. 2009 Aug;205(2):442-50
pubmed: 19203752
Nat Rev Immunol. 2006 Jan;6(1):33-43
pubmed: 16341139
Adv Cancer Res. 2014;123:1-34
pubmed: 25081524
Biomacromolecules. 2017 Oct 9;18(10):3387-3399
pubmed: 28846389
J Exp Med. 2000 Sep 18;192(6):769-79
pubmed: 10993908
Chem Commun (Camb). 2003 Jul 7;(13):1518-9
pubmed: 12868732
Drug Deliv. 2005 Nov-Dec;12(6):327-42
pubmed: 16253949
Nat Chem. 2009 Jul;1(4):276-88
pubmed: 21378870
Nat Chem. 2011 Mar;3(3):234-38
pubmed: 21336330
Biochemistry. 2007 Jun 12;46(23):6911-20
pubmed: 17503783
Structure. 2010 May 12;18(5):649-56
pubmed: 20462498
Biomacromolecules. 2017 Jun 12;18(6):1713-1723
pubmed: 28398752
Science. 2013 Aug 9;341(6146):1238149
pubmed: 23929982
Biomacromolecules. 2007 Jul;8(7):2129-34
pubmed: 17585806
Adv Mater. 2011 Mar 25;23(12):H41-56
pubmed: 21394792
Chem Commun (Camb). 2017 Aug 10;53(65):9163-9166
pubmed: 28766595
Glycobiology. 2001 Jan;11(1):57-64
pubmed: 11181562
J Am Chem Soc. 2012 May 23;134(20):8474-9
pubmed: 22519420
Nat Rev Immunol. 2018 Jun;18(6):374-389
pubmed: 29581532
Talanta. 2001 Jan 26;53(5):1021-9
pubmed: 18968193
Nat Struct Mol Biol. 2007 Mar;14(3):234-9
pubmed: 17293874
Biomacromolecules. 2012 Jun 11;13(6):1845-52
pubmed: 22483345
Eur J Med Res. 2016 Feb 13;21:5
pubmed: 26873038