Parathyroid carcinoma in chronic renal disease - a case series of three patients and review of literature.
Parathyroid carcinoma
end-stage renal disease
haemodialysis
parathyroidectomy
secondary hyperparathyroidism
Journal
Acta chirurgica Belgica
ISSN: 0001-5458
Titre abrégé: Acta Chir Belg
Pays: England
ID NLM: 0370571
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
pubmed:
31
8
2021
medline:
3
3
2023
entrez:
30
8
2021
Statut:
ppublish
Résumé
Apart from being a rare endocrine tumor, parathyroid carcinoma is also one of the rarest malignancies in human beings. Parathyroid carcinoma is even more uncommon in haemodialysis patients with end-stage renal disease. The pathogenesis of parathyroid hyperplasia in haemodialysis patients is well known, but the mechanism of development of parathyroid carcinoma in these patients remains unclear. Three cases of parathyroid carcinoma in haemodialysis patients are presented in this study: a 69-year-old male patient and two female patients (67 and 61 years old). In all cases parathyroid carcinoma infiltrated the ipsilateral thyroid lobe and in one patient the right laryngeal nerve was involved as well. One patient underwent three surgical procedures. After surgical treatment, all patients were normocalcaemic and showed a significant reduction in PTH levels. In patients with secondary hyperparathyroidism, who develop parathyroid carcinoma, surgical resection is the only viable treatment option.
Sections du résumé
BACKGROUND
UNASSIGNED
Apart from being a rare endocrine tumor, parathyroid carcinoma is also one of the rarest malignancies in human beings. Parathyroid carcinoma is even more uncommon in haemodialysis patients with end-stage renal disease. The pathogenesis of parathyroid hyperplasia in haemodialysis patients is well known, but the mechanism of development of parathyroid carcinoma in these patients remains unclear.
METHODS
UNASSIGNED
Three cases of parathyroid carcinoma in haemodialysis patients are presented in this study: a 69-year-old male patient and two female patients (67 and 61 years old). In all cases parathyroid carcinoma infiltrated the ipsilateral thyroid lobe and in one patient the right laryngeal nerve was involved as well. One patient underwent three surgical procedures.
RESULTS
UNASSIGNED
After surgical treatment, all patients were normocalcaemic and showed a significant reduction in PTH levels.
CONCLUSION
UNASSIGNED
In patients with secondary hyperparathyroidism, who develop parathyroid carcinoma, surgical resection is the only viable treatment option.
Identifiants
pubmed: 34459368
doi: 10.1080/00015458.2021.1970438
doi:
Substances chimiques
Parathyroid Hormone
0
Types de publication
Review
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM