Non-ribosomal insights into ribosomal P2 protein in Plasmodium falciparum-infected erythrocytes.
Cell Division
/ physiology
Erythrocytes
/ parasitology
Humans
Malaria, Falciparum
/ pathology
Membrane Proteins
/ metabolism
Phosphoproteins
/ antagonists & inhibitors
Plasmodium falciparum
/ genetics
Protein Transport
/ physiology
Ribosomal Proteins
/ antagonists & inhibitors
Ribosomes
/ metabolism
Plasmodium falciparum
cell division
channel protein complex
malaria
nuclear division
protein oligomerization
protein trafficking
ribosomal P-protein
Journal
MicrobiologyOpen
ISSN: 2045-8827
Titre abrégé: Microbiologyopen
Pays: England
ID NLM: 101588314
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
08
04
2021
accepted:
10
04
2021
entrez:
30
8
2021
pubmed:
31
8
2021
medline:
6
1
2022
Statut:
ppublish
Résumé
The enormous complexity of the eukaryotic ribosome has been a real challenge in unlocking the mechanistic aspects of its amazing molecular function during mRNA translation and many non-canonical activities of ribosomal proteins in eukaryotic cells. While exploring the uncanny nature of ribosomal P proteins in malaria parasites Plasmodium falciparum, the 60S stalk ribosomal P2 protein has been shown to get exported to the infected erythrocyte (IE) surface as an SDS-resistant oligomer during the early to the mid-trophozoite stage. Inhibiting IE surface P2 either by monoclonal antibody or through genetic knockdown resulted in nuclear division arrest of the parasite. This strange and serendipitous finding has led us to explore more about un-canonical cell biology and the structural involvement of P2 protein in Plasmodium in the search for a novel biochemical role during parasite propagation in the human host.
Identifiants
pubmed: 34459544
doi: 10.1002/mbo3.1188
pmc: PMC8380560
doi:
Substances chimiques
Membrane Proteins
0
Phosphoproteins
0
Ribosomal Proteins
0
phosphoprotein P2, ribosomal
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1188Informations de copyright
© 2021 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd.
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