Novel GRHL3 Variants in a South African Cohort With Cleft Lip and Palate.
GRHL3
South Africa
cleft lip and cleft palate
Journal
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
ISSN: 1545-1569
Titre abrégé: Cleft Palate Craniofac J
Pays: United States
ID NLM: 9102566
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
pubmed:
31
8
2021
medline:
27
8
2022
entrez:
30
8
2021
Statut:
ppublish
Résumé
The etiology of cleft palate (CP) is poorly understood compared with that of cleft lip with or without palate (CL ± P). Recently, variants in Grainyhead like transcription factor 3 ( We sequenced the exons of The cleft clinics from 2 public, tertiary hospitals in Durban, South Africa (SA), namely Inkosi Albert Luthuli Central Hospital and KwaZulu-Natal Children's Hospital. One hundred patients with CL ± P and their parents. Saliva samples were collected. To ascertain the genetic variants in the Five variants in This study provides further evidence that variants in
Identifiants
pubmed: 34459660
doi: 10.1177/10556656211038453
pmc: PMC9790085
mid: NIHMS1856790
doi:
Substances chimiques
DNA-Binding Proteins
0
GRHL3 protein, human
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1125-1130Subventions
Organisme : NIDCR NIH HHS
ID : K43 DE029427
Pays : United States
Organisme : NIDCR NIH HHS
ID : R00 DE022378
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE028300
Pays : United States
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