Ribosome Protection as a Mechanism of Lincosamide Resistance in Mycobacterium abscessus.
ABCF
Mycobacterium abscessus
lincosamide resistance
ribosome protection
whiB7
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
18 10 2021
18 10 2021
Historique:
pubmed:
31
8
2021
medline:
3
11
2021
entrez:
30
8
2021
Statut:
ppublish
Résumé
Mycobacterium abscessus has emerged as a successful pathogen owing to its intrinsic drug resistance. Macrolide and lincosamide antibiotics share overlapping binding sites within the ribosome and common resistance pathways. Nevertheless, while M. abscessus is initially susceptible to macrolides, they are completely resistant to the lincosamide antibiotics. Here, we have used RNA sequencing to determine the changes in gene expression in M. abscessus upon exposure to the lincosamide, clindamycin (CLY). We show that
Identifiants
pubmed: 34460298
doi: 10.1128/AAC.01184-21
pmc: PMC8522731
doi:
Substances chimiques
Anti-Bacterial Agents
0
Lincosamides
0
Macrolides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0118421Subventions
Organisme : NIAID NIH HHS
ID : R01 AI155473
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI146774
Pays : United States
Organisme : National Institutes of Health (NIH)
ID : AI155473
Organisme : HHS | National Institutes of Health (NIH)
ID : AI146774
Références
Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):19528-19537
pubmed: 32723821
Front Microbiol. 2017 Apr 25;8:681
pubmed: 28487675
Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):629-634
pubmed: 31871194
J Clin Microbiol. 2015 Mar;53(3):875-8
pubmed: 25568437
Nat Rev Microbiol. 2005 Nov;3(11):870-81
pubmed: 16261170
Genome Biol. 2015 Jan 13;16:1
pubmed: 25583448
Antimicrob Agents Chemother. 2016 Apr 22;60(5):2895-900
pubmed: 26926649
J Antimicrob Chemother. 2014 Jun;69(6):1559-63
pubmed: 24500188
Nucleic Acids Res. 2013 Aug;41(14):e140
pubmed: 23716638
Antimicrob Agents Chemother. 2006 Oct;50(10):3476-8
pubmed: 17005837
Clin Infect Dis. 2002 Feb 15;34(4):482-92
pubmed: 11797175
Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):8978-8983
pubmed: 30126986
J Mol Biol. 2019 Aug 23;431(18):3568-3590
pubmed: 30597160
Biochem Biophys Res Commun. 2004 Feb 27;315(1):166-73
pubmed: 15013441
FEBS J. 2011 Nov;278(21):4015-24
pubmed: 21848804
Antimicrob Agents Chemother. 2003 Oct;47(10):3053-60
pubmed: 14506008
Nucleic Acids Res. 2018 Apr 20;46(7):3753-3763
pubmed: 29415157
J Antimicrob Chemother. 2012 Apr;67(4):810-8
pubmed: 22290346
Infect Drug Resist. 2020 Feb 12;13:447-454
pubmed: 32104016
J Biol Chem. 2008 Sep 12;283(37):25332-25339
pubmed: 18562322
Thorax. 2016 Jan;71(1):88-90
pubmed: 26678435
Am J Respir Crit Care Med. 2007 Feb 15;175(4):367-416
pubmed: 17277290
Enferm Infecc Microbiol Clin (Engl Ed). 2018 Nov;36(9):586-592
pubmed: 29217094
Antimicrob Agents Chemother. 2009 Apr;53(4):1367-76
pubmed: 19171799
Antimicrob Agents Chemother. 2018 May 25;62(6):
pubmed: 29632012
Antimicrob Agents Chemother. 2006 Jul;50(7):2560-2
pubmed: 16801446
Antimicrob Agents Chemother. 2016 Sep 23;60(10):6374-6
pubmed: 27458221
Respir Med. 2009 Oct;103(10):1448-55
pubmed: 19467851
Expert Opin Pharmacother. 2012 May;13(7):967-86
pubmed: 22519767
Nat Struct Mol Biol. 2014 Feb;21(2):152-9
pubmed: 24389465
Antimicrob Agents Chemother. 2017 Oct 24;61(11):
pubmed: 28874378
Front Microbiol. 2018 Sep 12;9:2179
pubmed: 30258428
mBio. 2016 Mar 22;7(2):e01975
pubmed: 27006457
Antimicrob Agents Chemother. 2021 Feb 17;65(3):
pubmed: 33318008
J Antimicrob Chemother. 2005 Feb;55(2):170-7
pubmed: 15590712
J Antimicrob Chemother. 2017 Feb;72(2):376-384
pubmed: 27999011
FEMS Microbiol Lett. 2008 May;282(2):147-59
pubmed: 18399991
Proc Natl Acad Sci U S A. 2018 May 15;115(20):5157-5162
pubmed: 29712846
Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0033021
pubmed: 34097497
ACS Infect Dis. 2018 Mar 9;4(3):239-246
pubmed: 29376318