2-Carba-lysophosphatidic acid is a novel β-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition.
Alcohol Oxidoreductases
/ chemistry
HEK293 Cells
HeLa Cells
Humans
Lysophospholipids
/ chemistry
Molecular Docking Simulation
Phosphoric Diester Hydrolases
/ metabolism
Phosphorylation
Receptors, Lysophosphatidic Acid
/ chemistry
Recombinant Proteins
/ chemistry
Signal Transduction
Solvents
Transforming Growth Factor alpha
/ metabolism
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
30 08 2021
30 08 2021
Historique:
received:
18
05
2021
accepted:
18
08
2021
entrez:
31
8
2021
pubmed:
1
9
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator that, along with its chemically stabilized analogue 2-carba-cyclic phosphatidic acid (2ccPA), induces various biological activities in vitro and in vivo. Although cPA is similar to lysophosphatidic acid (LPA) in structure and synthetic pathway, some of cPA biological functions apparently differ from those reported for LPA. We previously investigated the pharmacokinetic profile of 2ccPA, which was found to be rapidly degraded, especially in acidic conditions, yielding an unidentified compound. Thus, not only cPA but also its degradation compound may contribute to the biological activity of cPA, at least for 2ccPA. In this study, we determined the structure and examined the biological activities of 2-carba-lysophosphatidic acid (2carbaLPA) as a 2ccPA degradation compound, which is a type of β-LPA analogue. Similar to LPA and cPA, 2carbaLPA induced the phosphorylation of the extracellular signal-regulated kinase and showed potent agonism for all known LPA receptors (LPA
Identifiants
pubmed: 34462512
doi: 10.1038/s41598-021-96931-2
pii: 10.1038/s41598-021-96931-2
pmc: PMC8405639
doi:
Substances chimiques
Lysophospholipids
0
Receptors, Lysophosphatidic Acid
0
Recombinant Proteins
0
Solvents
0
Transforming Growth Factor alpha
0
Alcohol Oxidoreductases
EC 1.1.-
choline oxidase
EC 1.1.3.17
Phosphoric Diester Hydrolases
EC 3.1.4.-
alkylglycerophosphoethanolamine phosphodiesterase
EC 3.1.4.39
lysophosphatidic acid
PG6M3969SG
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
17360Informations de copyright
© 2021. The Author(s).
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