Campylobacter jejuni genotypes are associated with post-infection irritable bowel syndrome in humans.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
30 08 2021
30 08 2021
Historique:
received:
18
11
2020
accepted:
13
08
2021
entrez:
31
8
2021
pubmed:
1
9
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Campylobacter enterocolitis may lead to post-infection irritable bowel syndrome (PI-IBS) and while some C. jejuni strains are more likely than others to cause human disease, genomic and virulence characteristics promoting PI-IBS development remain uncharacterized. We combined pangenome-wide association studies and phenotypic assays to compare C. jejuni isolates from patients who developed PI-IBS with those who did not. We show that variation in bacterial stress response (Cj0145_phoX), adhesion protein (Cj0628_CapA), and core biosynthetic pathway genes (biotin: Cj0308_bioD; purine: Cj0514_purQ; isoprenoid: Cj0894c_ispH) were associated with PI-IBS development. In vitro assays demonstrated greater adhesion, invasion, IL-8 and TNFα secretion on colonocytes with PI-IBS compared to PI-no-IBS strains. A risk-score for PI-IBS development was generated using 22 genomic markers, four of which were from Cj1631c, a putative heme oxidase gene linked to virulence. Our finding that specific Campylobacter genotypes confer greater in vitro virulence and increased risk of PI-IBS has potential to improve understanding of the complex host-pathogen interactions underlying this condition.
Identifiants
pubmed: 34462533
doi: 10.1038/s42003-021-02554-8
pii: 10.1038/s42003-021-02554-8
pmc: PMC8405632
doi:
Banques de données
figshare
['10.6084/m9.figshare.12493106']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1015Subventions
Organisme : NIDDK NIH HHS
ID : K23 DK103911
Pays : United States
Organisme : NIDDK NIH HHS
ID : R03 DK120745
Pays : United States
Organisme : Medical Research Council
ID : MR/L015080/1
Pays : United Kingdom
Informations de copyright
© 2021. The Author(s).
Références
Genome Med. 2014 Nov 20;6(11):90
pubmed: 25422674
Genome Res. 2019 Feb;29(2):304-316
pubmed: 30679308
Mol Microbiol. 2000 Feb;35(3):529-41
pubmed: 10672176
Mol Microbiol. 2000 Aug;37(3):501-14
pubmed: 10931344
Int J Food Microbiol. 2009 Aug 31;134(1-2):96-103
pubmed: 19269051
Front Microbiol. 2018 Nov 16;9:2674
pubmed: 30505293
Proc Natl Acad Sci U S A. 2020 May 19;117(20):11018-11028
pubmed: 32366649
Antimicrob Agents Chemother. 2014;58(1):212-20
pubmed: 24145532
J Med Microbiol. 1995 May;42(5):312-27
pubmed: 7752210
J Appl Microbiol. 2010 Feb;108(2):591-9
pubmed: 19702866
Transl Res. 2020 Sep;223:76-88
pubmed: 32438073
Nature. 2000 Feb 10;403(6770):665-8
pubmed: 10688204
J Bacteriol. 2004 Jan;186(2):503-17
pubmed: 14702320
Vet Immunol Immunopathol. 2014 Nov 15;162(1-2):14-23
pubmed: 25307769
J Mol Biol. 2020 Sep 4;432(19):5244-5258
pubmed: 32710984
Biotechniques. 2004 Oct;37(4):590, 592-4, 596-7
pubmed: 15517971
Mol Biol Evol. 2013 Apr;30(4):772-80
pubmed: 23329690
Mol Microbiol. 2004 Jul;53(2):541-53
pubmed: 15228533
Mol Microbiol. 2001 May;40(3):769-77
pubmed: 11359581
J Bacteriol. 2007 Mar;189(5):1856-65
pubmed: 17172331
BMC Biol. 2018 Aug 2;16(1):84
pubmed: 30071832
Bioinformatics. 2018 Jan 15;34(2):292-293
pubmed: 29028899
Gut. 2012 Jul;61(7):997-1006
pubmed: 22180058
J Bacteriol. 2016 Sep 22;198(20):2829-40
pubmed: 27481928
Nat Microbiol. 2016 Apr 04;1:16041
pubmed: 27572646
Nat Commun. 2019 May 15;10(1):2176
pubmed: 31092817
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Bioinformatics. 2014 May 1;30(9):1312-3
pubmed: 24451623
Infect Immun. 2009 Jun;77(6):2399-407
pubmed: 19349427
PLoS One. 2019 Jul 10;14(7):e0219088
pubmed: 31291319
Mol Ecol. 2014 May;23(10):2442-51
pubmed: 24689900
Sci Rep. 2018 Jan 30;8(1):1902
pubmed: 29382867
Infect Immun. 2012 Sep;80(9):3307-18
pubmed: 22778098
Gut. 2020 Jan;69(1):62-73
pubmed: 30923071
Gut. 2000 Dec;47(6):804-11
pubmed: 11076879
Gigascience. 2019 Oct 1;8(10):
pubmed: 31598686
Infect Immun. 2000 Dec;68(12):6535-41
pubmed: 11083762
J Bacteriol. 2008 Aug;190(16):5681-9
pubmed: 18556784
Nat Commun. 2018 Nov 28;9(1):5034
pubmed: 30487573
Front Cell Infect Microbiol. 2012 Mar 20;2:31
pubmed: 22919623
mSphere. 2015 Dec 02;1(1):
pubmed: 27303676
Am J Gastroenterol. 2006 Jun;101(6):1288-94
pubmed: 16771951
Clin Microbiol Infect. 2014 Jun;20(6):524-9
pubmed: 24102802
J Antimicrob Chemother. 2017 Oct 1;72(10):2764-2768
pubmed: 29091202
Gut. 2014 Nov;63(11):1737-45
pubmed: 24310267
Clin Gastroenterol Hepatol. 2021 Sep;19(9):1855-1863.e1
pubmed: 32711045
Trends Microbiol. 2007 Oct;15(10):456-61
pubmed: 17920274
BMJ Open. 2012 Jul 12;2(4):
pubmed: 22798256
FEMS Microbiol Rev. 2005 Apr;29(2):377-90
pubmed: 15808749
BMC Biol. 2017 Oct 27;15(1):97
pubmed: 29078764
Genome Res. 2008 May;18(5):821-9
pubmed: 18349386
Mol Microbiol. 2011 Jun;80(5):1296-312
pubmed: 21435039
Mol Microbiol. 2009 Aug;73(4):650-62
pubmed: 19627497
Cell Commun Signal. 2013 Oct 21;11:79
pubmed: 24144181
Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):10047-52
pubmed: 22665794
Aliment Pharmacol Ther. 2015 Feb;41(4):342-51
pubmed: 25521822
Gastroenterology. 2017 Apr;152(5):1042-1054.e1
pubmed: 28069350
Infect Immun. 2008 Oct;76(10):4431-8
pubmed: 18644887
Appl Environ Microbiol. 2015 Jul;81(13):4546-52
pubmed: 25911489
J Immunol. 2013 Dec 1;191(11):5636-45
pubmed: 24166974
PLoS Genet. 2018 May 8;14(5):e1007333
pubmed: 29738521
Adv Exp Med Biol. 2020;1282:115-125
pubmed: 32329029
J Clin Microbiol. 2011 May;49(5):1750-7
pubmed: 21411576
Infect Immun. 1999 Jan;67(1):88-93
pubmed: 9864200
Gastroenterology. 2006 Apr;130(5):1480-91
pubmed: 16678561
Microbiology (Reading). 2005 Jul;151(Pt 7):2451-2458
pubmed: 16000735
J Clin Invest. 2004 Dec;114(11):1659-65
pubmed: 15578098
PLoS One. 2009 Sep 30;4(9):e7257
pubmed: 19789649
J Clin Microbiol. 2005 Jun;43(6):2771-81
pubmed: 15956396
Gastroenterology. 2019 Jan;156(1):46-58.e7
pubmed: 30009817
J Infect Dis. 2001 Sep 1;184(5):606-9
pubmed: 11474430
Biochemistry. 2004 Aug 17;43(32):10314-27
pubmed: 15301530
Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1195-1200
pubmed: 30610179
Mol Biol Evol. 2018 Feb 1;35(2):518-522
pubmed: 29077904
Mol Biol Evol. 2015 Jan;32(1):268-74
pubmed: 25371430
Mucosal Immunol. 2018 Mar;11(2):575-577
pubmed: 29091080
J Bacteriol. 2006 Nov;188(22):7862-75
pubmed: 16980451
PLoS One. 2015 Oct 23;10(10):e0141182
pubmed: 26496441
mBio. 2020 Jul 7;11(4):
pubmed: 32636251
Cell Mol Life Sci. 2018 Apr;75(7):1163-1178
pubmed: 29080090
PLoS One. 2015 Dec 02;10(12):e0144349
pubmed: 26630669
PLoS Pathog. 2008 Jan;4(1):e14
pubmed: 18225954
Aliment Pharmacol Ther. 1997 Apr;11(2):395-402
pubmed: 9146781
Clin Infect Dis. 2009 Apr 15;48(8):1072-8
pubmed: 19275496
PLoS One. 2014 Mar 27;9(3):e92798
pubmed: 24676150
Nucleic Acids Res. 2016 Jan 4;44(D1):D694-7
pubmed: 26578559
Am J Gastroenterol. 2009 Sep;104(9):2267-74
pubmed: 19568228
J Clin Microbiol. 2001 Jan;39(1):14-23
pubmed: 11136741
Gastroenterology. 2006 Aug;131(2):445-50; quiz 660
pubmed: 16890598
Infect Immun. 2002 Dec;70(12):6665-71
pubmed: 12438340
PLoS Comput Biol. 2015 Feb 12;11(2):e1004041
pubmed: 25675341
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1653-7
pubmed: 22139190
Curr Protoc Bioinformatics. 2010 Sep;Chapter 11:Unit 11.5
pubmed: 20836074
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Nov;1862(11):1404-1413
pubmed: 27956138
Microbes Infect. 2009 Oct;11(12):988-94
pubmed: 19631279
PLoS One. 2011;6(12):e29045
pubmed: 22194985
Mol Microbiol. 2005 Jan;55(1):90-103
pubmed: 15612919
Gut. 1985 Sep;26(9):945-51
pubmed: 4029720
J Med Microbiol. 1999 May;48(5):461-469
pubmed: 10229543
Infect Immun. 2008 Aug;76(8):3390-8
pubmed: 18490463
BMC Genomics. 2007 Jun 12;8:162
pubmed: 17565669
Infect Immun. 2006 Aug;74(8):4694-707
pubmed: 16861657
World J Gastroenterol. 2008 Dec 28;14(48):7345-52
pubmed: 19109868
Gastroenterology. 2003 Dec;125(6):1651-9
pubmed: 14724817
PLoS Negl Trop Dis. 2020 Aug 10;14(8):e0008533
pubmed: 32776937
Microb Genom. 2019 Jul;5(7):
pubmed: 31310201
Aliment Pharmacol Ther. 2004 Dec;20(11-12):1317-22
pubmed: 15606393
Nat Microbiol. 2017 Oct;2(10):1381-1388
pubmed: 28785103
Microb Genom. 2016 Nov 30;2(11):e000093
pubmed: 28348833
Bioorg Chem. 2008 Dec;36(6):312-20
pubmed: 18845311
PLoS Comput Biol. 2018 Feb 5;14(2):e1005958
pubmed: 29401456
PLoS One. 2011;6(10):e26880
pubmed: 22039552
J Bacteriol. 2004 Jun;186(11):3296-303
pubmed: 15150214
J Bacteriol. 2010 Jan;192(1):68-76
pubmed: 19880595
Microorganisms. 2020 Apr 07;8(4):
pubmed: 32272707
J Bacteriol. 2008 Feb;190(3):1097-107
pubmed: 17993532
Mol Microbiol. 2006 Oct;62(1):278-91
pubmed: 16956379
Pediatr Res. 2008 Dec;64(6):599-604
pubmed: 18679160
Gut. 2013 Jul;62(7):985-94
pubmed: 22684480