Serum resistin is predictive marker of development of new digital ulcers in systemic sclerosis.
Angiogenesis
Digital ulcers
Resistin
Systemic sclerosis
Journal
Clinical and experimental medicine
ISSN: 1591-9528
Titre abrégé: Clin Exp Med
Pays: Italy
ID NLM: 100973405
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
24
05
2021
accepted:
19
08
2021
pubmed:
1
9
2021
medline:
3
8
2022
entrez:
31
8
2021
Statut:
ppublish
Résumé
Systemic sclerosis (SSc) is autoimmune disease characterized by endothelial dysfunction and microvascular damage. Resistin has been implied in microvascular dysfunction. Objective of this study is to evaluate the association between baseline resistin and development of new digital ulcers (DUs) in SSc patients. At baseline, serum resistin has been assessed in 70 female SSc patients and 26 healthy controls (HC). In SSc patients, clinical assessment was performed at baseline and after a 52-weeks follow-up. Serum resistin level was increased in SSc patients compared to HC [5.89 ng/ml (2.5 ng/ml-8.1 ng/ml) vs 2.3 ng/ml (0.4 ng/ml-2.4 ng/ml), p = 0.0004)]. Resistin was lower (p = 0.005) in SSc patients with early capillaroscopic pattern than patients with active or late capillaroscopic pattern [2.49 ng/ml (0.89 ng/ml-5.81 ng/ml) vs 7.11 ng/ml (3.48 ng/ml-11.35 ng/ml) and 6.49 ng/ml (3.35 ng/ml-8.87 ng/ml), respectively]. After a 52-weeks follow-up, 34 (48.6%) patients developed new DUs. Median serum resistin was significantly higher in patients with new DUs than in patients without new DUs [6.54 ng/ml (3.35 ng/ml-11.02 ng/ml) vs 4.78 ng/ml (1.06 ng/ml-7.6 ng/ml), p = 0.019]. Kaplan-Meier curves show a significantly reduced free survival from DUs in patients with increased resistin (p = 0.002). In multivariate analysis, resistin is associated with the development of new DUs. Increased serum resistin level is a predictive marker of new DUs in SSc.
Identifiants
pubmed: 34462844
doi: 10.1007/s10238-021-00756-2
pii: 10.1007/s10238-021-00756-2
pmc: PMC9338111
doi:
Substances chimiques
Biomarkers
0
RETN protein, human
0
Resistin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
421-426Informations de copyright
© 2021. The Author(s).
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