IGF1 Gene Therapy Reversed Cognitive Deficits and Restored Hippocampal Alterations After Chronic Spinal Cord Injury.
Animals
Cognition
/ physiology
Cognitive Dysfunction
/ etiology
Genetic Therapy
Hippocampus
/ metabolism
Insulin-Like Growth Factor I
/ genetics
Male
Microglia
/ metabolism
Neurogenesis
/ physiology
Neuronal Plasticity
/ physiology
Neurons
/ metabolism
Rats
Rats, Sprague-Dawley
Spinal Cord Injuries
/ complications
Cognition
Gene therapy
Hippocampus
IGF1
Microglia
Neurogenesis
Journal
Molecular neurobiology
ISSN: 1559-1182
Titre abrégé: Mol Neurobiol
Pays: United States
ID NLM: 8900963
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
04
12
2020
accepted:
22
08
2021
pubmed:
1
9
2021
medline:
18
3
2022
entrez:
31
8
2021
Statut:
ppublish
Résumé
The hippocampus is implicated in the generation of memory and learning, processes which involve extensive neuroplasticity. The generation of hippocampal adult-born neurons is particularly regulated by glial cells of the neurogenic niche and the surrounding microenvironment. Interestingly, recent evidence has shown that spinal cord injury (SCI) in rodents leads to hippocampal neuroinflammation, neurogenesis reduction, and cognitive impairments. In this scenario, the aim of this work was to evaluate whether an adenoviral vector expressing IGF1 could reverse hippocampal alterations and cognitive deficits after chronic SCI. SCI caused neurogenesis reduction and impairments of both recognition and working memories. We also found that SCI increased the number of hypertrophic arginase-1 negative microglia concomitant with the decrease of the number of ramified surveillance microglia in the hilus, molecular layer, and subgranular zone of the dentate gyrus. RAd-IGF1 treatment restored neurogenesis and improved recognition and working memory impairments. In addition, RAd-IGF1 gene therapy modulated differentially hippocampal regions. In the hilus and molecular layer, IGF1 gene therapy recovered the number of surveillance microglia coincident with a reduction of hypertrophic microglia cell number. However, in the neurogenic niche, IGF1 reduced the number of ramified microglia and increased the number of hypertrophic microglia, which as a whole expressed arginase-1. In summary, RAd-IGF1 gene therapy might surge as a new therapeutic strategy for patients with hippocampal microglial alterations and cognitive deficits such as those with spinal cord injury and other neurodegenerative diseases.
Identifiants
pubmed: 34463925
doi: 10.1007/s12035-021-02545-0
pii: 10.1007/s12035-021-02545-0
doi:
Substances chimiques
Insulin-Like Growth Factor I
67763-96-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6186-6202Subventions
Organisme : Consejo Nacional de Investigaciones Científicas y Técnicas
ID : PIP 00301
Organisme : Consejo Nacional de Investigaciones Científicas y Técnicas
ID : PIP 0618
Organisme : Agencia Nacional de Promoción Científica y Tecnológica
ID : PICT 0509
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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