Frailty, aging, and periodontal disease: Basic biologic considerations.
aging
cell biology
frailty
inflammation
periodontal disease
Journal
Periodontology 2000
ISSN: 1600-0757
Titre abrégé: Periodontol 2000
Pays: Denmark
ID NLM: 9313276
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
entrez:
31
8
2021
pubmed:
1
9
2021
medline:
21
10
2021
Statut:
ppublish
Résumé
Aging is associated with the development of disease. Periodontal disease is one of the many diseases and conditions that increase in prevalence with age. In addition to the traditional focus on individual age-related conditions, there is now a greater recognition that multisystem conditions such as frailty play an important role in the health of older populations. Frailty is a clinical condition in older adults that increases the risk of adverse health outcomes. Both frailty and periodontal disease are common chronic conditions in older populations and share several risk factors. There is likely a bidirectional relationship between periodontal disease and frailty. Comorbid systemic diseases, poor physical functioning, and limited ability to self-care in frail older people have been implicated as underlying the association between frailty and periodontal disease. In addition, both frailty and periodontal disease also have strong associations with inflammatory dysregulation and other age-related pathophysiologic changes that may similarly underlie their development and progression. Investigating age-related changes in immune cells that regulate inflammation may lead to a better understanding of age-related disease and could lead to therapeutic targets for the improved management of frailty and periodontal disease.
Identifiants
pubmed: 34463998
doi: 10.1111/prd.12380
pmc: PMC8771712
mid: NIHMS1771250
doi:
Substances chimiques
Biological Products
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Pagination
143-156Subventions
Organisme : Medical Research Council
ID : G1002391
Pays : United Kingdom
Organisme : NIDCR NIH HHS
ID : K08 DE029505
Pays : United States
Organisme : NIDCR NIH HHS
ID : R03 DE028505
Pays : United States
Informations de copyright
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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