The role of maternal high fat diet on mouse pup metabolic endpoints following perinatal PFAS and PFAS mixture exposure.
Alkanesulfonic Acids
/ toxicity
Animals
Caprylates
/ toxicity
Diet, High-Fat
/ adverse effects
Environmental Pollutants
/ toxicity
Female
Fluorocarbons
/ toxicity
Lipid Metabolism
/ drug effects
Liver
/ drug effects
Male
Maternal Exposure
/ adverse effects
Mice
Pregnancy
Prenatal Exposure Delayed Effects
/ physiopathology
Sulfonic Acids
/ toxicity
Liver
Mixtures
Perfluoroalkyl substances (PFAS)
Perinatal
Journal
Toxicology
ISSN: 1879-3185
Titre abrégé: Toxicology
Pays: Ireland
ID NLM: 0361055
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
05
02
2021
revised:
24
08
2021
accepted:
26
08
2021
pubmed:
1
9
2021
medline:
28
12
2021
entrez:
31
8
2021
Statut:
ppublish
Résumé
Per- and polyfluoroalkyl substances (PFAS) are a family of chemicals that are ubiquitous in the environment. Some of these chemicals, such as perfluorooctanesulfonic acid (PFOS), perfluorohexanesulfonate (PFHxS) and perfluorooctanoic acid (PFOA), are found in human sera and have been shown to cause liver steatosis and reduce postnatal survival and growth in rodents. The purpose of this work is to evaluate the impact of diet and PFAS exposure to mouse dam (mus musculus) on the risk to pup liver and metabolism endpoints later in life, as well as evaluate PFAS partitioning to pups. Timed-pregnant dams were fed a standard chow diet or 60 % kcal high fat diet (HFD). Dams were administered either vehicle, 1 mg/kg PFOA, 1 mg/kg PFOS, 1 mg/kg PFHxS, or a PFAS mixture (1 mg/kg of each PFOA, PFOS, and PFHxS) daily via oral gavage from gestation day 1 until postnatal day (PND) 20. At PND 21, livers of dams and 2 pups of each sex were evaluated for lipid changes while remaining pups were weaned to the same diet as the dam for an additional 10 weeks. Dam and pup serum at PND 21 and PND 90 were also evaluated for PFAS concentration, alanine aminotransferase (ALT), leptin and adiponectin, and glycosylated hemoglobin A1c. Perinatal exposure to a HFD, as expected, increased pup body weight, maternal liver weight, pup liver triglycerides, pup serum ALT, and pup serum leptin. PFOA and the PFAS mixture increased liver weights, and. treatment with all three compounds increased liver triglycerides. The maternal HFD increased dam and pup serum PFAS levels, however, was protective against PFOA-induced increase in serum ALT and observed increases in liver triglycerides. The PFAS mixture had very distinct effects when compared to single compound treatment, suggesting some cumulative effects, particularly when evaluating PFAS transfer from dam to pup. This data highlights the importance of diet and mixtures when evaluating liver effect of PFAS and PFAS partitioning.
Identifiants
pubmed: 34464680
pii: S0300-483X(21)00244-4
doi: 10.1016/j.tox.2021.152921
pmc: PMC8554779
mid: NIHMS1736781
pii:
doi:
Substances chimiques
Alkanesulfonic Acids
0
Caprylates
0
Environmental Pollutants
0
Fluorocarbons
0
Sulfonic Acids
0
perfluorohexanesulfonic acid
355-46-4
perfluorooctanoic acid
947VD76D3L
perfluorooctane sulfonic acid
9H2MAI21CL
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
152921Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103430
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES027706
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
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