Antiviral effect of multipurpose contact lens disinfecting solutions against coronavirus.
Contact lens disinfection
Coronavirus
Hydrogen peroxide
Iodine
Quaternary ammonium
Journal
Contact lens & anterior eye : the journal of the British Contact Lens Association
ISSN: 1476-5411
Titre abrégé: Cont Lens Anterior Eye
Pays: England
ID NLM: 9712714
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
15
06
2021
revised:
14
08
2021
accepted:
23
08
2021
pubmed:
2
9
2021
medline:
28
9
2022
entrez:
1
9
2021
Statut:
ppublish
Résumé
To evaluate the antiviral potential of five multipurpose disinfecting solutions against coronavirus (mouse hepatitis virus, a surrogate for SARS-CoV-2 human corona virus). Test solutions (Biotrue, renu Advanced [Bausch and Lomb], ACUVUE RevitaLens [Johnson and Johnson Vision], cleadew [Ophtecs corp.] or AOSept Plus [Alcon]) were mixed with the coronavirus mouse hepatitis virus at 10 The three multipurpose disinfecting solutions Biotrue (containing PHMB and polyquaternium-1), renu Advanced (PHMB, polyquaternium-1 and alexidine) and ACUVUE RevitaLens (polyquaternium-1 and alexidine) did not kill the coronavirus at the manufacturers recommended disinfection time in the stand alone test. After treatment, the virus's titer (3.8 ± 0.2 log This study shows that oxidative contact lens disinfecting solutions (i.e. those containing povidone-iodine or hydrogen peroxide) provide superior antiviral activity against a coronavirus surrogate of SARS-CoV-2, unless the full regimen test (rub, rinse, disinfect) is used.
Identifiants
pubmed: 34465537
pii: S1367-0484(21)00147-8
doi: 10.1016/j.clae.2021.101513
pmc: PMC8390374
pii:
doi:
Substances chimiques
Antiviral Agents
0
Biguanides
0
Contact Lens Solutions
0
Disinfectants
0
Phosphates
0
Povidone-Iodine
85H0HZU99M
Hydrogen Peroxide
BBX060AN9V
alexidine
GVN71CAL3G
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101513Informations de copyright
Copyright © 2021 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors MY and AKV declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. One author, MW, is a member of the Scientific Advisory Board of Ophtecs corp. whose cleadew disinfectant was tested in this study.