Kallistatin limits abdominal aortic aneurysm by attenuating generation of reactive oxygen species and apoptosis.
Aged
Aged, 80 and over
Animals
Aorta, Abdominal
/ metabolism
Aortic Aneurysm, Abdominal
/ etiology
Apoptosis
Atherosclerosis
/ etiology
Disease Models, Animal
Humans
Male
Mice
Mice, Inbred C57BL
Mice, Knockout, ApoE
Oxidative Stress
Reactive Oxygen Species
/ metabolism
Serpins
/ administration & dosage
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
31 08 2021
31 08 2021
Historique:
received:
24
05
2021
accepted:
20
08
2021
entrez:
1
9
2021
pubmed:
2
9
2021
medline:
9
11
2021
Statut:
epublish
Résumé
Inflammation, vascular smooth muscle cell apoptosis and oxidative stress are believed to play important roles in abdominal aortic aneurysm (AAA) pathogenesis. Human kallistatin (KAL; gene SERPINA4) is a serine proteinase inhibitor previously shown to inhibit inflammation, apoptosis and oxidative stress. The aim of this study was to investigate the role of KAL in AAA through studies in experimental mouse models and patients. Serum KAL concentration was negatively associated with the diagnosis and growth of human AAA. Transgenic overexpression of the human KAL gene (KS-Tg) or administration of recombinant human KAL (rhKAL) inhibited AAA in the calcium phosphate (CaPO
Identifiants
pubmed: 34465809
doi: 10.1038/s41598-021-97042-8
pii: 10.1038/s41598-021-97042-8
pmc: PMC8408144
doi:
Substances chimiques
Reactive Oxygen Species
0
Serpins
0
kallistatin
0
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
17451Informations de copyright
© 2021. The Author(s).
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