Korsakoff syndrome: An overlook (Review).
GABA receptors
Korsakoff syndome
Wernicke's encephalopathy
addiction
alcohol
neurobiology
neurogenesis
Journal
Experimental and therapeutic medicine
ISSN: 1792-1015
Titre abrégé: Exp Ther Med
Pays: Greece
ID NLM: 101531947
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
18
06
2021
accepted:
20
07
2021
entrez:
1
9
2021
pubmed:
2
9
2021
medline:
2
9
2021
Statut:
ppublish
Résumé
This review aimed to analyze the latest neurobiological findings regarding Korsakoff syndrome, since alcoholism is the most prevalent addiction worldwide. In addition, we analyzed the optimal treatment that can be administered in order to minimize the symptoms and improve the outcome of these patients. The disruption of memory circuits within the brain of alcoholic patients results in the amnestic syndrome known as Korsakoff syndrome. It is generally characterized by a chronic neuropsychiatric syndrome caused by vitamin B1 (thiamine) deficiency. Other categories of patients can develop Korsakoff syndrome without consuming alcohol such as AIDS patients, terminally ill cancer patients, or patients with chronic infections and malnutrition. Vitamin B1 is required in the Krebs cycle for production of adenosine triphosphate (ATP). It is also a cofactor in the production of acetylcholine and certain neurotransmitters. Alcohol consumption can decrease the intake, gastrointestinal absorption and cellular utilization of vitamin B1. Treatment of alcohol withdrawal along with high doses of vitamin B1 can improve the general outcome of patients. A small percentage of patients can recover from Wernicke's encephalopathy with no permanent brain damage. The onset of Korsakoff syndrome darkens the prognosis. Alcohol abstinence is an absolute recommendation and prevents the extension of neural damage.
Identifiants
pubmed: 34466144
doi: 10.3892/etm.2021.10566
pii: ETM-0-0-10566
pmc: PMC8383329
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1132Informations de copyright
Copyright: © Popa et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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