Polymersomes Decorated with the SARS-CoV-2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity.
Journal
ACS central science
ISSN: 2374-7943
Titre abrégé: ACS Cent Sci
Pays: United States
ID NLM: 101660035
Informations de publication
Date de publication:
25 Aug 2021
25 Aug 2021
Historique:
received:
18
05
2021
entrez:
1
9
2021
pubmed:
2
9
2021
medline:
2
9
2021
Statut:
ppublish
Résumé
The COVID-19 pandemic underscores the need for rapid, safe, and effective vaccines. In contrast to some traditional vaccines, nanoparticle-based subunit vaccines are particularly efficient in trafficking antigens to lymph nodes, where they induce potent immune cell activation. Here, we developed a strategy to decorate the surface of oxidation-sensitive polymersomes with multiple copies of the SARS-CoV-2 spike protein receptor-binding domain (RBD) to mimic the physical form of a virus particle. We evaluated the vaccination efficacy of these surface-decorated polymersomes (RBD
Identifiants
pubmed: 34466656
doi: 10.1021/acscentsci.1c00596
pmc: PMC8315245
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1368-1380Subventions
Organisme : NCI NIH HHS
ID : P30 CA014599
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007281
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007090
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA219304
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007605
Pays : United States
Organisme : NCI NIH HHS
ID : F30 CA221250
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201400008C
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2021 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare the following competing financial interest(s): M.A.S. and J.A.H. have patents related to the polymersome technology and interests in LantaBio, which has licensed those patents.
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