Protocol for remapping of place cells in disease mouse models.
Behavior
Model Organisms
Neuroscience
Journal
STAR protocols
ISSN: 2666-1667
Titre abrégé: STAR Protoc
Pays: United States
ID NLM: 101769501
Informations de publication
Date de publication:
17 09 2021
17 09 2021
Historique:
entrez:
1
9
2021
pubmed:
2
9
2021
medline:
2
9
2021
Statut:
epublish
Résumé
Hippocampal place cells and entorhinal grid cells exhibit distinct spike patterns in different environments called "remapping," and we have recently shown that remapping of place cells becomes disrupted in a mouse model of Alzheimer's disease. Here, we describe our protocol for investigating remapping of place cells and grid cells using a custom-made electrophysiology device, with detailed descriptions and problem-solving tips for the construction and implantation of the recording device. We also provide steps for behavioral training, recording, and data analysis. For complete details on the use and execution of this protocol, please refer to Jun et al. (2020).
Identifiants
pubmed: 34467228
doi: 10.1016/j.xpro.2021.100759
pii: S2666-1667(21)00465-2
pmc: PMC8384906
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
100759Subventions
Organisme : NIA NIH HHS
ID : F31 AG069500
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG063864
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG066806
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH121736
Pays : United States
Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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