Investigation of structural brain correlates of neurological soft signs in individuals at ultra-high risk for psychosis.
Grey matter volume
Neurological soft signs
Transition
Ultra-high risk
Voxel-based morphometry
Journal
European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
21
02
2021
accepted:
04
07
2021
pubmed:
2
9
2021
medline:
19
2
2022
entrez:
1
9
2021
Statut:
ppublish
Résumé
Increased severity of neurological soft signs (NSS) in schizophrenia have been associated with abnormal brain morphology in cerebello-thalamo-cortical structures, but it is unclear whether similar structures underlie NSS prior to the onset of psychosis. The present study investigated the relationship between severity of NSS and grey matter volume (GMV) in individuals at ultra-high risk for psychosis (UHR) stratified for later conversion to psychosis. Structural T1-weighted MRI scans were obtained from 56 antipsychotic-naïve UHR individuals and 35 healthy controls (HC). The UHR individuals had follow-up data (mean follow-up: 5.2 years) to ascertain clinical outcome. Using whole-brain voxel-based morphometry, the relationship between NSS and GMV at baseline was assessed in UHR, HC, as well as individuals who later transitioned (UHR-P, n = 25) and did not transition (UHR-NP, n = 31) to psychosis. NSS total and subscale scores except motor coordination were significantly higher in UHR compared to HC. Higher signs were also found in UHR-P, but not UHR-NP. Total NSS was not associated with GMV in the whole sample or in each group. However, in UHR-P individuals, greater deficits in sensory integration was associated with lower GMV in the left cerebellum, right insula, and right middle frontal gyrus. In conclusion, NSS are present in UHR individuals, particularly those who later transitioned to a psychotic disorder. While these signs show little overall variation with GMV, the association of sensory integration deficits with lower GMV in UHR-P suggests that certain brain areas may be implicated in the development of specific neurological abnormalities in the psychosis prodrome.
Identifiants
pubmed: 34467451
doi: 10.1007/s00406-021-01300-9
pii: 10.1007/s00406-021-01300-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1475-1485Subventions
Organisme : National Health and Medical Research Council
ID : 970598
Organisme : National Health and Medical Research Council
ID : 350241
Organisme : National Health and Medical Research Council
ID : 981112
Organisme : NHMRC Senior Principal Research Fellowships
ID : 628386
Organisme : NHMRC Senior Principal Research Fellowships
ID : 1105825
Organisme : Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award
ID : 18722
Organisme : NHMRC Principal Research Fellowship
ID : 1136829
Organisme : NHMRC Early Career Fellowship
ID : 1088785
Organisme : NHMRC Senior Research Fellowship
ID : 1137687
Organisme : NHMRC Career Development Fellowship
ID : 1148793
Organisme : NHMRC Investigator Grant
ID : 1177370
Organisme : Brain and Behavior Research Foundation (NARSAD) Young Investigator Award
ID : 21660
Organisme : National Key Research and Development Programme
ID : 2016YFC0906402
Informations de copyright
© 2021. Springer-Verlag GmbH Germany, part of Springer Nature.
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