Recommendations for diagnosis and treatment of methemoglobinemia.
Journal
American journal of hematology
ISSN: 1096-8652
Titre abrégé: Am J Hematol
Pays: United States
ID NLM: 7610369
Informations de publication
Date de publication:
01 12 2021
01 12 2021
Historique:
revised:
24
08
2021
received:
16
07
2021
accepted:
25
08
2021
pubmed:
2
9
2021
medline:
4
1
2022
entrez:
1
9
2021
Statut:
ppublish
Résumé
Methemoglobinemia is a rare disorder associated with oxidization of divalent ferro-iron of hemoglobin (Hb) to ferri-iron of methemoglobin (MetHb). Methemoglobinemia can result from either inherited or acquired processes. Acquired forms are the most common, mainly due to the exposure to substances that cause oxidation of the Hb both directly or indirectly. Inherited forms are due either to autosomal recessive variants in the CYB5R3 gene or to autosomal dominant variants in the globin genes, collectively known as HbM disease. Our recommendations are based on a systematic literature search. A series of questions regarding the key signs and symptoms, the methods for diagnosis, the clinical management in neonatal/childhood/adulthood period, and the therapeutic approach of methemoglobinemia were formulated and the relative recommendations were produced. An agreement was obtained using a Delphi-like approach and the experts panel reached a final consensus >75% of agreement for all the questions.
Identifiants
pubmed: 34467556
doi: 10.1002/ajh.26340
pmc: PMC9291883
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1666-1678Informations de copyright
© 2021 The Authors. American Journal of Hematology published by Wiley Periodicals LLC.
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