City-level SARS-CoV-2 sewage surveillance.
Early warning
Normalized viral load
Population monitoring
SARS-CoV-2
Wastewater epidemiology
Journal
Chemosphere
ISSN: 1879-1298
Titre abrégé: Chemosphere
Pays: England
ID NLM: 0320657
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
04
02
2021
revised:
21
04
2021
accepted:
09
06
2021
pubmed:
2
9
2021
medline:
10
9
2021
entrez:
1
9
2021
Statut:
ppublish
Résumé
The COVID-19 pandemic created a global crisis impacting not only healthcare systems, but also economics and society. Therefore, it is important to find novel methods for monitoring disease activity. Recent data have indicated that fecal shedding of SARS-CoV-2 is common, and that viral RNA can be detected in wastewater. This suggests that wastewater monitoring is a potentially efficient tool for both epidemiological surveillance, and early warning for SARS-CoV-2 circulation at the population level. In this study we sampled an urban wastewater infrastructure in the city of Ashkelon (̴ 150,000 population), Israel, during the end of the first COVID-19 wave in May 2020 when the number of infections seemed to be waning. We were able to show varying presence of SARS-CoV-2 RNA in wastewater from several locations in the city during two sampling periods, before the resurgence was clinically apparent. This was expressed with a new index, Normalized Viral Load (NVL) which can be used in different area scales to define levels of virus activity such as red (high) or green (no), and to follow morbidity in the population at the tested area. The rise in viral load between the two sampling periods (one week apart) indicated an increase in morbidity that was evident two weeks to a month later in the population. Thus, this methodology may provide an early indication for SARS-CoV-2 infection outbreak in a population before an outbreak is clinically apparent.
Identifiants
pubmed: 34467943
pii: S0045-6535(21)01666-0
doi: 10.1016/j.chemosphere.2021.131194
pmc: PMC8217074
pii:
doi:
Substances chimiques
RNA, Viral
0
Sewage
0
Waste Water
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
131194Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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