Exposure to Perfluoroalkyl Substances and Glucose Homeostasis in Youth.

Adolescent Alkanesulfonic Acids Child Diabetes Mellitus, Type 2 Environmental Pollutants Female Fluorocarbons Glucose Homeostasis Humans Male Young Adult

Journal

Environmental health perspectives
ISSN: 1552-9924
Titre abrégé: Environ Health Perspect
Pays: United States
ID NLM: 0330411

Informations de publication

Date de publication:
09 2021
Historique:
entrez: 1 9 2021
pubmed: 2 9 2021
medline: 17 3 2022
Statut: ppublish

Résumé

Exposure to per- and polyfluoroalkyl substances (PFAS), a prevalent class of persistent pollutants, may increase the risk of type 2 diabetes. We examined associations between PFAS exposure and glucose metabolism in youth. Overweight/obese adolescents from the Study of Latino Adolescents at Risk of Type 2 Diabetes (SOLAR; In females from the SOLAR, high perfluorohexane sulfonate (PFHxS) levels ( Youth exposure to PFHxS was associated with dysregulated glucose metabolism in females, which may be due to changes in

Sections du résumé

BACKGROUND
Exposure to per- and polyfluoroalkyl substances (PFAS), a prevalent class of persistent pollutants, may increase the risk of type 2 diabetes.
OBJECTIVE
We examined associations between PFAS exposure and glucose metabolism in youth.
METHODS
Overweight/obese adolescents from the Study of Latino Adolescents at Risk of Type 2 Diabetes (SOLAR;
RESULTS
In females from the SOLAR, high perfluorohexane sulfonate (PFHxS) levels (
DISCUSSION
Youth exposure to PFHxS was associated with dysregulated glucose metabolism in females, which may be due to changes in

Identifiants

DOI: 10.1289/EHP9200 PMID: 34468161 PMC: PMC8409228
pubmed: 34468161
doi: 10.1289/EHP9200
pmc: PMC8409228
doi:

Substances chimiques

Alkanesulfonic Acids 0
Environmental Pollutants 0
Fluorocarbons 0
Glucose IY9XDZ35W2

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

97002

Subventions

Organisme : NIEHS NIH HHS
ID : R21 ES029681
Pays : United States
Organisme : NIEHS NIH HHS
ID : P01 ES022845
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES030691
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES028903
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES029328
Pays : United States
Organisme : NIEHS NIH HHS
ID : R00 ES027870
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES030364
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES013678
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA196569
Pays : United States
Organisme : NIEHS NIH HHS
ID : R00 ES027853
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029944
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES007048
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014089
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES023515
Pays : United States

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Auteurs

Jesse A Goodrich (JA)

Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA.

Tanya L Alderete (TL)

Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.

Brittney O Baumert (BO)

Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA.

Kiros Berhane (K)

Department of Biostatistics, Columbia University, New York, New York, USA.

Zhanghua Chen (Z)

Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA.

Frank D Gilliland (FD)

Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA.

Michael I Goran (MI)

Department of Pediatrics, Keck School of Medicine, Los Angeles, California, USA.
Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.

Xin Hu (X)

Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Dean P Jones (DP)

Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Katerina Margetaki (K)

Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA.

Sarah Rock (S)

Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA.

Nikos Stratakis (N)

Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA.

Damaskini Valvi (D)

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Douglas I Walker (DI)

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

David V Conti (DV)

Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA.

Leda Chatzi (L)

Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Exposure to Perfluoroalkyl Substances and...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Acides du soufre › Acides sulfoniques › Acides alcanesulfoniques › Exposure to Perfluoroalkyl Substances and...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Exposure to Perfluoroalkyl Substances and...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Exposure to Perfluoroalkyl Substances and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Exposure to Perfluoroalkyl Substances and...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Hydrocarbures fluorés › Fluorocarbones › Exposure to Perfluoroalkyl Substances and...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Exposure to Perfluoroalkyl Substances and...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Exposure to Perfluoroalkyl Substances and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Exposure to Perfluoroalkyl Substances and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Exposure to Perfluoroalkyl Substances and...