Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent
Amidohydrolases
/ antagonists & inhibitors
Animals
Anti-Inflammatory Agents
/ chemical synthesis
Enzyme Inhibitors
/ chemical synthesis
Humans
Male
Mice, Inbred C57BL
Microsomes, Liver
/ metabolism
Molecular Docking Simulation
Molecular Structure
Protein Binding
Pyrazoles
/ chemical synthesis
Rats, Sprague-Dawley
Structure-Activity Relationship
Tropanes
/ chemical synthesis
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
23 09 2021
23 09 2021
Historique:
pubmed:
2
9
2021
medline:
15
12
2021
entrez:
1
9
2021
Statut:
ppublish
Résumé
Inhibition of intracellular
Identifiants
pubmed: 34469137
doi: 10.1021/acs.jmedchem.1c00575
pmc: PMC8474119
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Enzyme Inhibitors
0
Pyrazoles
0
Tropanes
0
Amidohydrolases
EC 3.5.-
N-acylethanolamine-hydrolyzing acid amidase, rat
EC 3.5.1.-
NAAA protein, human
EC 3.5.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
13327-13355Références
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