Controlling Polymer Morphologies by Intramolecular and Intermolecular Dynamic Covalent Iron(III)/Catechol Complexation-From Polypeptide Single Chain Nanoparticles to Hydrogels.
albumin hydrogels
albumin nanoparticles
dynamic covalent materials
iron complexes
single chain folding
stimulus-responsiveness
Journal
Macromolecular rapid communications
ISSN: 1521-3927
Titre abrégé: Macromol Rapid Commun
Pays: Germany
ID NLM: 9888239
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
revised:
20
08
2021
received:
02
07
2021
pubmed:
2
9
2021
medline:
24
6
2022
entrez:
1
9
2021
Statut:
ppublish
Résumé
Responsive biomaterials, tunable from the molecular to the macroscopic scale, are attractive for various applications in nanotechnology. Herein, a long polypeptide chain derived from the abundant serum protein human serum albumin is cross-linked by dynamic-coordinative iron(III)/catechol bonds. By tuning the binding stoichiometry and the pH, reversible intramolecular folding into polypeptide nanoparticles with controllable sizes is achieved. Moreover, upon varying the stoichiometry, intermolecular cross-links become predominant yielding smart and tunable macroscopic protein hydrogels. By adjusting the intra- and intermolecular interactions, biocompatible and biodegradable materials are formed with varying morphologies and dimensions covering several lengths scales featuring rapid gelation without toxic reagents, fast and autonomous self-healing, tunable mechanical properties, and high adaptability to local environmental conditions. Such material characteristics can be particularly attractive for tissue engineering approaches to recreate soft tissues matrices with highly customizable features in a fast and simple fashion.
Identifiants
pubmed: 34469614
doi: 10.1002/marc.202100413
doi:
Substances chimiques
Biocompatible Materials
0
Catechols
0
Hydrogels
0
Peptides
0
Polymers
0
Iron
E1UOL152H7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2100413Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : 316249678 - SFB 1279 (C01)
Organisme : Federal Ministry of Education and Research of Germany
ID : 13XP5086F
Organisme : Max Planck-Bristol Centre for Minimal Biology
Organisme : Bundesministerium für Bildung und Forschung
ID : 13XP5086F
Informations de copyright
© 2021 The Authors. Macromolecular Rapid Communications published by Wiley-VCH GmbH.
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