A subset of Kupffer cells regulates metabolism through the expression of CD36.
CD206
CD36
Kupffer cells
heterogeneity
high fat diet
liver
macrophages
metabolism
scRNA-seq
single cell
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
14 09 2021
14 09 2021
Historique:
received:
04
12
2020
revised:
27
04
2021
accepted:
09
08
2021
pubmed:
2
9
2021
medline:
10
11
2021
entrez:
1
9
2021
Statut:
ppublish
Résumé
Tissue macrophages are immune cells whose phenotypes and functions are dictated by origin and niches. However, tissues are complex environments, and macrophage heterogeneity within the same organ has been overlooked so far. Here, we used high-dimensional approaches to characterize macrophage populations in the murine liver. We identified two distinct populations among embryonically derived Kupffer cells (KCs) sharing a core signature while differentially expressing numerous genes and proteins: a major CD206
Identifiants
pubmed: 34469775
pii: S1074-7613(21)00336-8
doi: 10.1016/j.immuni.2021.08.006
pii:
doi:
Substances chimiques
CD36 Antigens
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2101-2116.e6Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests C.B., M.A., and F.G. are inventors on a patent filed, owned, and managed by A(∗)ccelerate technologies Pte Ltd, A-STAR, Singapore, on technology related to the work presented in this manuscript.