Sciatic neurectomy-related cortical bone loss exhibits delayed onset yet stabilises more rapidly than trabecular bone.
Bone loss trajectory
Bone mass and shape
Bone resorption
Cortical and trabecular bone
Disuse
Journal
Bone reports
ISSN: 2352-1872
Titre abrégé: Bone Rep
Pays: United States
ID NLM: 101646176
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
30
04
2021
revised:
06
08
2021
accepted:
08
08
2021
entrez:
2
9
2021
pubmed:
3
9
2021
medline:
3
9
2021
Statut:
epublish
Résumé
Disuse osteoporosis occurs after extended periods of bed rest or nerve damage leading to increased risk of fracture. It remains to be established, however, whether the trajectory of bone loss is equivalent in bone's cortical and trabecular compartments following long-term periods of reduced loading. Herein, we evaluate sciatic neurectomy-related cortical and trabecular bone loss in the tibia by microCT. The right hind limb of seventeen 12 week-old female mice was subjected to sciatic neurectomy (right, SN; left, contralateral internal control) and the animals were sacrificed in four groups (
Identifiants
pubmed: 34471655
doi: 10.1016/j.bonr.2021.101116
pii: S2352-1872(21)00373-9
pmc: PMC8387754
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101116Subventions
Organisme : Medical Research Council
ID : MR/R025673/1
Pays : United Kingdom
Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
None.
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