Potassium and Sodium Channels and the Warburg Effect: Biophysical Regulation of Cancer Metabolism.
Warburg effect
cancer
ion channels
Journal
Bioelectricity
ISSN: 2576-3113
Titre abrégé: Bioelectricity
Pays: United States
ID NLM: 101747121
Informations de publication
Date de publication:
01 Sep 2019
01 Sep 2019
Historique:
entrez:
2
9
2021
pubmed:
1
9
2019
medline:
1
9
2019
Statut:
ppublish
Résumé
Ion channels are progressively emerging as a novel class of membrane proteins expressed in several types of human cancers and regulating the different aspects of cancer cell behavior. The metabolism of cancer cells, usually composed by a variable proportion of respiration, glycolysis, and glutaminolysis, leads to the excessive production of acidic metabolic products. The presence of these acidic metabolites inside the cells results in intracellular acidosis, and hinders survival and proliferation. For this reason, tumor cells activate mechanisms of pH control that produce a constitutive increase in intracellular pH (pH
Identifiants
pubmed: 34471821
doi: 10.1089/bioe.2019.0017
pii: 10.1089/bioe.2019.0017
pmc: PMC8370285
doi:
Types de publication
Journal Article
Langues
eng
Pagination
188-200Informations de copyright
Copyright 2019, Mary Ann Liebert, Inc., publishers.
Déclaration de conflit d'intérêts
No competing financial interests exist.
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