Recent Advances in Electrochemotherapy.
electrochemotherapy
human oncology
preclinical studies
veterinary oncology
Journal
Bioelectricity
ISSN: 2576-3113
Titre abrégé: Bioelectricity
Pays: United States
ID NLM: 101747121
Informations de publication
Date de publication:
01 Dec 2019
01 Dec 2019
Historique:
entrez:
2
9
2021
pubmed:
1
12
2019
medline:
1
12
2019
Statut:
ppublish
Résumé
Electrochemotherapy is gaining recognition as an effective local therapy that uses systemically or intratumorally injected bleomycin or cisplatin with electroporation as a delivery system that brings drugs into the cells to exert their cytotoxic effects. Preclinical work is still ongoing, testing new drugs, seeking the best treatment combination with other treatment modalities, and exploring new sets of pulses for effective tissue electroporation. The applications of electrochemotherapy are being fully exploited in veterinary oncology, where electrochemotherapy, because of its simple execution, has a relatively good cost-benefit ratio and is used in the treatment of cutaneous tumors. In human oncology, electrochemotherapy is fully recognized as a local therapy for cutaneous tumors and metastases. Its effectiveness is being explored in combination with immunomodulatory drugs. However, the development of electrochemotherapy is directed into the treatment of deep-seated tumors with a percutaneous approach. Because of the vast number of reports, this review discusses the articles published in the past 5 years.
Identifiants
pubmed: 34471824
doi: 10.1089/bioe.2019.0028
pii: 10.1089/bioe.2019.0028
pmc: PMC8370294
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
204-213Informations de copyright
Copyright 2019, Mary Ann Liebert, Inc., publishers.
Déclaration de conflit d'intérêts
No competing financial interests exist.
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