Endoplasmic reticulum stress response and bile acid signatures associate with multi-strain seroresponsiveness during elderly influenza vaccination.
Cell biology
Clinical microbiology
Immunology
Virology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
24 Sep 2021
24 Sep 2021
Historique:
received:
23
06
2020
revised:
25
03
2021
accepted:
09
08
2021
entrez:
2
9
2021
pubmed:
3
9
2021
medline:
3
9
2021
Statut:
epublish
Résumé
The elderly are an important target for influenza vaccination, and the determination of factors that underlie immune responsiveness is clinically valuable. We evaluated the immune and metabolic profiles of 205 elderly Singaporeans administered with Vaxigrip. Despite high seroprotection rates, we observed heterogeneity in the response. We stratified the cohort into complete (CR) or incomplete responders (IR), where IR exhibited signs of accelerated T cell aging. We found a higher upregulation of genes associated with the B-cell endoplasmic-reticulum stress response in CR, where XBP-1 acts as a key upstream regulator. B-cells from IR were incapable of matching the level of XBP-1 upregulation observed in CR after inducing ER stress with tunicamycin
Identifiants
pubmed: 34471863
doi: 10.1016/j.isci.2021.102970
pii: S2589-0042(21)00938-X
pmc: PMC8387917
doi:
Types de publication
Journal Article
Langues
eng
Pagination
102970Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
C.C., C.H, D.L. and L.Q. are employees of Sanofi Pasteur. N.B. is an employee of Nestlé Research Center. The remaining authors declare no competing interest.
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