The Influence of Cesarean Delivery on Ovarian Reserve: a Prospective Cohort Study.
Anti-Mullerian hormone
Cesarean delivery
Fertility
Ovarian reserve
Vaginal delivery
Journal
Reproductive sciences (Thousand Oaks, Calif.)
ISSN: 1933-7205
Titre abrégé: Reprod Sci
Pays: United States
ID NLM: 101291249
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
06
06
2021
accepted:
26
08
2021
pubmed:
3
9
2021
medline:
23
3
2022
entrez:
2
9
2021
Statut:
ppublish
Résumé
To assess the association between cesarean delivery and ovarian reserve, as compared to vaginal delivery. A prospective case control study conducted at a single tertiary medical center between June 2018 and June 2019. Study population included women with singleton pregnancy that underwent first cesarean delivery that were compared to women undergoing normal vaginal delivery. Women with low ovarian reserve, endometriosis, previous pelvic surgery, chronic maternal disease, and active labor were excluded. Ovarian reserve was estimated by Anti-Mullerian hormone (AMH) levels that was determined twice for each participant: up to a week before and 3 months after delivery. Primary outcome was defined as the delta in AMH levels. Data were analyzed by non-parametric tests. During the study period, 135 women were enrolled, of them 63 (47%) underwent cesarean delivery and 72 (53%) had vaginal delivery. Women in the cesarean delivery group were older (34 (31-38) vs. 32 (29-35); p = 0.001); nevertheless, AMH levels measured before delivery were comparable between the two groups (0.92 (0.51-1.79) vs. 0.95 (0.51-1.79) pg/mL; p = 0.42). AMH levels measured after delivery were more than doubled in the study and control groups (2.15 (1.24-3.05) vs. 2.62 (1.05-5.09); p = 0.50), and delta AMH levels were also found comparable (1.25 (0.61-2.22) vs. 1.59 (0.63-3.41), respectively; p = 0.43). Linear regression analysis including age, mode of delivery, gestational age at delivery, and delta hemoglobin levels revealed that only maternal age was significantly associated with delta in AMH levels (B = - 0.09, p = 0.04). Cesarean delivery does not decrease ovarian reserve as estimated by AMH.
Identifiants
pubmed: 34472035
doi: 10.1007/s43032-021-00730-z
pii: 10.1007/s43032-021-00730-z
doi:
Substances chimiques
Anti-Mullerian Hormone
80497-65-0
Banques de données
ClinicalTrials.gov
['NCT02821702']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
639-645Informations de copyright
© 2021. Society for Reproductive Investigation.
Références
Taffel SM, Placek PJ, Liss T. Trends in the United States cesarean section rate and reasons for the 1980–85 rise. Am J Public Health. 1987;77(8):955–9.
doi: 10.2105/AJPH.77.8.955
Gregory KD, Curtin SC, Taffel SM, Notzon FC. Changes in indications for cesarean delivery: United States, 1985 and 1994. Am J Public Health. 1998;88(9):1384–7.
doi: 10.2105/AJPH.88.9.1384
Porter M, Bhattacharya S, van Teijlingen E, Templeton A, Group ROFCSRC. Does Caesarean section cause infertility? Hum Reprod. 2003;18(10):1983–6.
doi: 10.1093/humrep/deg402
Murphy DJ, Stirrat GM, Heron J, Team AS. The relationship between Caesarean section and subfertility in a population-based sample of 14 541 pregnancies. Hum Reprod. 2002;17(7):1914–7.
doi: 10.1093/humrep/17.7.1914
Hall MH, Campbell DM, Fraser C, Lemon J. Mode of delivery and future fertility. Br J Obstet Gynaecol. 1989;96(11):1297–303.
doi: 10.1111/j.1471-0528.1989.tb03227.x
Evers EC, McDermott KC, Blomquist JL, Handa VL. Mode of delivery and subsequent fertility. Hum Reprod. 2014;29(11):2569–74.
doi: 10.1093/humrep/deu197
Smith GC, Wood AM, Pell JP, Dobbie R. First cesarean birth and subsequent fertility. Fertil Steril. 2006;85(1):90–5.
doi: 10.1016/j.fertnstert.2005.07.1289
Kjerulff KH, Zhu J, Weisman CS, Ananth CV. First birth Caesarean section and subsequent fertility: a population-based study in the USA, 2000–2008. Hum Reprod. 2013;28(12):3349–57.
doi: 10.1093/humrep/det343
Elvander C, Dahlberg J, Andersson G, Cnattingius S. Mode of delivery and the probability of subsequent childbearing: a population-based register study. BJOG. 2015;122(12):1593–600.
doi: 10.1111/1471-0528.13021
Radin RG, Mikkelsen EM, Rothman KJ, Hatch EE, Sorensen HT, Riis AH, et al. Brief report: Cesarean delivery and subsequent fecundability. Epidemiology. 2016;27(6):889–93.
doi: 10.1097/EDE.0000000000000553
Chen Y, Pei H, Chang Y, Chen M, Wang H, Xie H, et al. The impact of endometrioma and laparoscopic cystectomy on ovarian reserve and the exploration of related factors assessed by serum anti-Mullerian hormone: a prospective cohort study. J Ovarian Res. 2014;7:108.
doi: 10.1186/s13048-014-0108-0
Mostaejeran F, Hamoush Z, Rouholamin S. Evaluation of antimullerian hormone levels before and after laparoscopic management of endometriosis. Adv Biomed Res. 2015;4:182.
pubmed: 26605221
pmcid: 4617155
Uncu G, Kasapoglu I, Ozerkan K, Seyhan A, Oral Yilmaztepe A, Ata B. Prospective assessment of the impact of endometriomas and their removal on ovarian reserve and determinants of the rate of decline in ovarian reserve. Hum Reprod. 2013;28(8):2140–5.
doi: 10.1093/humrep/det123
Chiang HJ, Lin PY, Huang FJ, Kung FT, Lin YJ, Sung PH, et al. The impact of previous ovarian surgery on ovarian reserve in patients with endometriosis. BMC Womens Health. 2015;15:74.
doi: 10.1186/s12905-015-0230-1
Kröncke T, David M. Uterine artery embolization (UAE) for myoma treatment–results of the 3rd radiologic gynecologic expert meeting. Rofo. 2010;182(7):615–7.
doi: 10.1055/s-0029-1245468
Steiner AZ, Herring AH, Kesner JS, Meadows JW, Stanczyk FZ, Hoberman S, et al. Antimüllerian hormone as a predictor of natural fecundability in women aged 30–42 years. Obstet Gynecol. 2011;117(4):798–804.
doi: 10.1097/AOG.0b013e3182116bc8
Depmann M, et al. Does AMH relate to timing of menopause? Results of an individual patient data meta- analysis. J Clin Endocrinol Metab. 2018.
Moolhuijsen LME, Visser JA. Anti-Müllerian hormone and ovarian reserve: update on assessing ovarian function. J Clin Endocrinol Metab. 2020;105(11).
Steiner AZ, Pritchard D, Stanczyk FZ, Kesner JS, Meadows JW, Herring AH, et al. Association between biomarkers of ovarian reserve and infertility among older women of reproductive age. JAMA. 2017;318(14):1367–76.
doi: 10.1001/jama.2017.14588
Haadsma ML, Bukman A, Groen H, Roeloffzen EM, Groenewoud ER, Heineman MJ, et al. The number of small antral follicles (2–6 mm) determines the outcome of endocrine ovarian reserve tests in a subfertile population. Hum Reprod. 2007;22(7):1925–31.
doi: 10.1093/humrep/dem081
Zarek SM, Mitchell EM, Sjaarda LA, Mumford SL, Silver RM, Stanford JB, et al. Is Anti-Müllerian Hormone associated with fecundability? Findings from the EAGeR trial. J Clin Endocrinol Metab. 2015;100(11):4215–21.
doi: 10.1210/jc.2015-2474
Weenen C, Laven JS, Von Bergh AR, Cranfield M, Groome NP, Visser JA, et al. Anti-Müllerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. Mol Hum Reprod. 2004;10(2):77–83.
doi: 10.1093/molehr/gah015
Broekmans FJ, Kwee J, Hendriks DJ, Mol BW, Lambalk CB. A systematic review of tests predicting ovarian reserve and IVF outcome. Hum Reprod Update. 2006;12(6):685–718.
doi: 10.1093/humupd/dml034
van Rooij IA, Broekmans FJ, te Velde ER, Fauser BC, Bancsi LF, de Jong FH, et al. Serum anti-Müllerian hormone levels: a novel measure of ovarian reserve. Hum Reprod. 2002;17(12):3065–71.
doi: 10.1093/humrep/17.12.3065
Baird DD, Dunson DB, Hill MC, Cousins D, Schectman JM. High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. Am J Obstet Gynecol. 2003;188(1):100–7.
doi: 10.1067/mob.2003.99
Shebl O, Ebner T, Sir A, Schreier-Lechner E, Mayer RB, Tews G, et al. Age-related distribution of basal serum AMH level in women of reproductive age and a presumably healthy cohort. Fertil Steril. 2011;95(2):832–4.
doi: 10.1016/j.fertnstert.2010.09.012
Ganer Herman H, Gluck O, Keidar R, Kerner R, Kovo M, Levran D, et al. Ovarian reserve following cesarean section with salpingectomy vs tubal ligation: a randomized trial. Am J Obstet Gynecol. 2017;217(4):472.e1-.e6.
doi: 10.1016/j.ajog.2017.04.028
Landersoe SK, Larsen EC, Forman JL, Birch Petersen K, Kroman MS, Frederiksen H, et al. Ovarian reserve markers and endocrine profile during oral contraception: is there a link between the degree of ovarian suppression and AMH? Gynecol Endocrinol. 2020;36(12):1090–5.
doi: 10.1080/09513590.2020.1756250
Moini A, Pirjani R, Rabiei M, Nurzadeh M, Sepidarkish M, Hosseini R, et al. Can delivery mode influence future ovarian reserve? Anti-Mullerian hormone levels and antral follicle count following cesarean section: a prospective cohort study. J Ovarian Res. 2019;12(1):83.
doi: 10.1186/s13048-019-0551-z
Gottvall K, Waldenström U. Does a traumatic birth experience have an impact on future reproduction? BJOG. 2002;109(3):254–60.
doi: 10.1111/j.1471-0528.2002.01200.x
Eijsink JJ, van der Leeuw-Harmsen L, van der Linden PJ. Pregnancy after Caesarean section: fewer or later? Hum Reprod. 2008;23(3):543–7.
doi: 10.1093/humrep/dem428
van Houten EL, Themmen AP, Visser JA. Anti-Müllerian hormone (AMH): regulator and marker of ovarian function. Ann Endocrinol (Paris). 2010;71(3):191–7.
doi: 10.1016/j.ando.2010.02.016
Broer SL, Broekmans FJ, Laven JS, Fauser BC. Anti-Müllerian hormone: ovarian reserve testing and its potential clinical implications. Hum Reprod Update. 2014;20(5):688–701.
doi: 10.1093/humupd/dmu020
La Marca A, Giulini S, Orvieto R, De Leo V, Volpe A. Anti-Müllerian hormone concentrations in maternal serum during pregnancy. Hum Reprod. 2005;20(6):1569–72.
doi: 10.1093/humrep/deh819
Grynnerup AG, Lindhard A, Sørensen S. The role of anti-Müllerian hormone in female fertility and infertility - an overview. Acta Obstet Gynecol Scand. 2012;91(11):1252–60.
doi: 10.1111/j.1600-0412.2012.01471.x
Stegmann BJ, Santillan M, Leader B, Smith E, Santillan D. Changes in antimüllerian hormone levels in early pregnancy are associated with preterm birth. Fertil Steril. 2015;104(2):347-55.e3.
doi: 10.1016/j.fertnstert.2015.04.044
Nelson SM, Stewart F, Fleming R, Freeman DJ. Longitudinal assessment of antimüllerian hormone during pregnancy-relationship with maternal adiposity, insulin, and adiponectin. Fertil Steril. 2010;93(4):1356–8.
doi: 10.1016/j.fertnstert.2009.07.1676
Köninger A, Kauth A, Schmidt B, Schmidt M, Yerlikaya G, Kasimir-Bauer S, et al. Anti-Mullerian-hormone levels during pregnancy and postpartum. Reprod Biol Endocrinol. 2013;11:60.
doi: 10.1186/1477-7827-11-60
Weghofer A, Dietrich W, Ortner I, Bieglmayer C, Barad D, Gleicher N. Anti-Mullerian hormone levels decline under hormonal suppression: a prospective analysis in fertile women after delivery. Reprod Biol Endocrinol. 2011;9:98.
doi: 10.1186/1477-7827-9-98
Lee TH, Liu CH, Huang CC, Hsieh KC, Lin PM, Lee MS. Impact of female age and male infertility on ovarian reserve markers to predict outcome of assisted reproduction technology cycles. Reprod Biol Endocrinol. 2009;7:100.
doi: 10.1186/1477-7827-7-100
Lambalk CB, van Disseldorp J, de Koning CH, Broekmans FJ. Testing ovarian reserve to predict age at menopause. Maturitas. 2009;63(4):280–91.
doi: 10.1016/j.maturitas.2009.06.007