Testing the association between tobacco smoking, alcohol consumption, and risk of periodontitis: A Mendelian randomization study.
Mendelian randomization
alcohol
periodontitis
tobacco smoking
Journal
Journal of clinical periodontology
ISSN: 1600-051X
Titre abrégé: J Clin Periodontol
Pays: United States
ID NLM: 0425123
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
05
08
2021
received:
30
06
2021
accepted:
24
08
2021
pubmed:
3
9
2021
medline:
1
12
2021
entrez:
2
9
2021
Statut:
ppublish
Résumé
To investigate the associations of tobacco smoking and alcohol consumption with periodontitis using Mendelian randomization (MR) analysis. We used 17 single nucleotide polymorphisms (SNPs) as instrumental variables (IVs) for the number of cigarettes per day from a genome-wide association study (GWAS) of 337,334 individuals, 109 SNPs for a lifetime smoking index from GWAS of 462,690 participants, and 33 SNPs for the number of drinks per week from GWAS of 941,280 individuals. The periodontitis GWAS included 12,289 cases and 22,326 controls. Wald ratios were obtained by dividing the SNP-periodontitis effects by SNP-exposure effects and pooled using an inverse-variance weighted model. Genetic liabilities for higher number of cigarettes per day (odds ratio [OR] per one standard deviation (1SD) increment = 1.56; 95% CI: 1.18-2.07, p-value = .0018, Q-value = .0054), lifetime smoking index (OR per 1SD = 1.26; 95% CI: 1.04-1.53, p-value = .0161, Q-value = .0242), and drinks per week (OR per 1SD = 1.41; 95% CI: 1.04-1.90, p-value = .0265, Q-value = .0265) were associated with increased odds of periodontitis. Estimates were consistent across robust and multivariable MR analyses. The findings of this MR analysis suggest an association between tobacco smoking and alcohol consumption with periodontitis.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1414-1420Informations de copyright
© 2021 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.
Références
Barr, T., Helms, C., Grant, K., & Messaoudi, I. (2016). Opposing effects of alcohol on the immune system. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 65, 242-251. https://doi.org/10.1016/j.pnpbp.2015.09.001
Brion, M. J., Shakhbazov, K., & Visscher, P. M. (2013). Calculating statistical power in Mendelian randomization studies. International Journal of Epidemiology, 42(5), 1497-1501. https://doi.org/10.1093/ije/dyt179
Burgess, S., Davies, N. M., & Thompson, S. G. (2014). Instrumental variable analysis with a nonlinear exposure-outcome relationship. Epidemiology, 25(6), 877-885. https://doi.org/10.1097/ede.0000000000000161
Burgess, S., Foley, C. N., & Zuber, V. (2018). Inferring causal relationships between risk factors and outcomes from genome-wide association study data. Annual Review of Genomics and Human Genetics, 19, 303-327. https://doi.org/10.1146/annurev-genom-083117-021731
Burgess, S., Small, D. S., & Thompson, S. G. (2017). A review of instrumental variable estimators for Mendelian randomization. Statistical Methods in Medical Research, 26(5), 2333-2355. https://doi.org/10.1177/0962280215597579
Burgess, S., Smith, G. D., Davies, N. M., Dudbridge, F., Gill, D., Glymour, M. M., Hartwig, F. P., Holmes, M. V., Minelli, C., Relton, C. L., & Theodoratou, E. (2020). Guidelines for performing Mendelian randomization investigations. Wellcome Open Research, 4(186), 186.
Burgess, S., & Thompson, S. G. (2011). Avoiding bias from weak instruments in Mendelian randomization studies. International Journal of Epidemiology, 40(3), 755-764. https://doi.org/10.1093/ije/dyr036
Chapple, I. L., Bouchard, P., Cagetti, M. G., Campus, G., Carra, M. C., Cocco, F., Nibali, L., Hujoel, P., Laine, M. L., Lingstrom, P., Manton, D. J., Montero, E., Pitts, N., Rangé, H., Schlueter, N., Teughels, W., Twetman, S., Van Loveren, C., Van der Weijden, F., … Schulte, A. G. (2017). Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: Consensus report of group 2 of the joint EFP/ORCA workshop on the boundaries between caries and periodontal diseases. Journal of Clinical Periodontology, 44(Suppl. 18), S39-S51. https://doi.org/10.1111/jcpe.12685
Collins, R., Bowman, L., Landray, M., & Peto, R. (2020). The magic of randomization versus the myth of real-world evidence. The New England Journal of Medicine, 382(7), 674-678. https://doi.org/10.1056/NEJMsb1901642
Danaei, G., Tavakkoli, M., & Hernán, M. A. (2012). Bias in observational studies of prevalent users: Lessons for comparative effectiveness research from a meta-analysis of statins. American Journal of Epidemiology, 175(4), 250-262.
Davey Smith, G., Holmes, M. V., Davies, N. M., & Ebrahim, S. (2020). Mendel's laws, Mendelian randomization and causal inference in observational data: Substantive and nomenclatural issues. European Journal of Epidemiology, 35(2), 99-111. https://doi.org/10.1007/s10654-020-00622-7
Davey Smith, G., & Phillips, A. N. (2020). Correlation without a cause: An epidemiological odyssey. International Journal of Epidemiology, 49(1), 4-14. https://doi.org/10.1093/ije/dyaa016
GBD 2019 Risk Factors Collaborators. (2020). Global burden of 87 risk factors in 204 countries and territories, 1990-2019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet, 396(10258), 1223-1249. https://doi.org/10.1016/s0140-6736(20)30752-2
Heaton, B., Applebaum, K. M., Rothman, K. J., Brooks, D. R., Heeren, T., Dietrich, T., & Garcia, R. I. (2014). The influence of prevalent cohort bias in the association between periodontal disease progression and incident coronary heart disease. Annals of Epidemiology, 24(10), 741-746. https://doi.org/10.1016/j.annepidem.2014.07.006
Hemani, G., Bowden, J., & Davey Smith, G. (2018). Evaluating the potential role of pleiotropy in Mendelian randomization studies. Human Molecular Genetics, 27(R2), R195-r208. https://doi.org/10.1093/hmg/ddy163
Jiang, Y., Zhou, X., Cheng, L., & Li, M. (2020). The impact of smoking on subgingival microflora: From periodontal health to disease. Frontiers in Microbiology, 11, 66. https://doi.org/10.3389/fmicb.2020.00066
Kamat, M. A., Blackshaw, J. A., Young, R., Surendran, P., Burgess, S., Danesh, J., Butterworth, A. S., & Staley, J. R. (2019). PhenoScanner V2: An expanded tool for searching human genotype-phenotype associations. Bioinformatics, 35, 4851-4853. https://doi.org/10.1093/bioinformatics/btz469
Labrecque, J., & Swanson, S. A. (2018). Understanding the assumptions underlying instrumental variable analyses: Abrief review of falsification strategies and related tools. Current Epidemiology Reports, 5(3), 214-220. https://doi.org/10.1007/s40471-018-0152-1
Labrecque, J. A., & Swanson, S. A. (2019). Interpretation and potential biases of Mendelian randomization estimates with time-varying exposures. American Journal of Epidemiology, 188(1), 231-238. https://doi.org/10.1093/aje/kwy204
Lee, J. J., Wedow, R., Okbay, A., Kong, E., Maghzian, O., Zacher, M., Nguyen-Viet, T. A., Bowers, P., Sidorenko, J., Linnér, R. K., Fontana, M. A., Kundu, T., Lee, C., Li, H., Li, R., Royer, R., Timshel, P. N., Walters, R. K., Willoughby, E. A., … Cesarini, D. (2018). Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics, 50(8), 1112-1121. https://doi.org/10.1038/s41588-018-0147-3
Leffondré, K., Abrahamowicz, M., Xiao, Y., & Siemiatycki, J. (2006). Modelling smoking history using a comprehensive smoking index: Application to lung cancer. Statistics in Medicine, 25(24), 4132-4146. https://doi.org/10.1002/sim.2680
Leite, F. R. M., Nascimento, G. G., Scheutz, F., & López, R. (2018). Effect of smoking on periodontitis: A systematic review and meta-regression. American Journal of Preventive Medicine, 54(6), 831-841. https://doi.org/10.1016/j.amepre.2018.02.014
Liu, M., Jiang, Y., Wedow, R., Li, Y., Brazel, D. M., Chen, F., Datta, G., Davila-Velderrain, J., McGuire, D., Tian, C., Zhan, X., 23andMe Research Team, HUNT All-In Psychiatry, Choquet, H., Docherty, A. R., Faul, J. D., Foerster, J. R., Fritsche, L. G., Gabrielsen, M. E., … Vrieze, S. (2019). Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Nature Genetics, 51(2), 237-244. https://doi.org/10.1038/s41588-018-0307-5
Mathur, M. B., & VanderWeele, T. J. (2020). Sensitivity analysis for unmeasured confounding in meta-analyses. Journal of the American Statistical Association, 115(529), 163-172. https://doi.org/10.1080/01621459.2018.1529598
Matthews, J. B., Chen, F. M., Milward, M. R., Ling, M. R., & Chapple, I. L. (2012). Neutrophil superoxide production in the presence of cigarette smoke extract, nicotine and cotinine. Journal of Clinical Periodontology, 39(7), 626-634. https://doi.org/10.1111/j.1600-051X.2012.01894.x
Munafò, M. R., & Smith, G. D. (2018). Robust research needs many lines of evidence. Nature, 553, 399-401.
Okamoto, Y., Tsuboi, S., Suzuki, S., Nakagaki, H., Ogura, Y., Maeda, K., & Tokudome, S. (2006). Effects of smoking and drinking habits on the incidence of periodontal disease and tooth loss among Japanese males: A 4-yr longitudinal study. Journal of Periodontal Research, 41(6), 560-566. https://doi.org/10.1111/j.1600-0765.2006.00907.x
Page, R. C., & Eke, P. I. (2007). Case definitions for use in population-based surveillance of periodontitis. Journal of Periodontology, 78(7 Suppl), 1387-1399. https://doi.org/10.1902/jop.2007.060264
Pitiphat, W., Merchant, A. T., Rimm, E. B., & Joshipura, K. J. (2003). Alcohol consumption increases periodontitis risk. Journal of Dental Research, 82(7), 509-513. https://doi.org/10.1177/154405910308200704
Pulikkotil, S. J., Nath, S., Dharamarajan, L., Jing, K. T., & Vaithilingam, R. D. (2020). Alcohol consumption is associated with periodontitis. A systematic review and meta-analysis of observational studies. Community Dental Health, 37(1), 12-21. https://doi.org/10.1922/CDH_4569Pulikkotil10
Pulit, S. L., Stoneman, C., Morris, A. P., Wood, A. R., Glastonbury, C. A., Tyrrell, J., Yengo, L., Ferreira, T., Marouli, E., Ji, Y., Yang, J., Jones, S., Beaumont, R., Croteau-Chonka, D. C., Winkler, T. W., GIANT Consortium, Hattersley, A. T., Loos, R. J. F., Hirschhorn, J. N., … Lindgren, C. M. (2019). Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. Human Molecular Genetics, 28(1), 166-174. https://doi.org/10.1093/hmg/ddy327
Sanderson, E., Davey Smith, G., Windmeijer, F., & Bowden, J. (2019). An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings. International Journal of Epidemiology, 48(3), 713-727. https://doi.org/10.1093/ije/dyy262
Sankaranarayanan, R., Saxlin, T., Knuuttila, M., Ylöstalo, P., & Suominen, A. L. (2020). Alcohol use and the development of periodontal pockets: An 11-year follow-up study. Journal of Periodontology, 91(12), 1621-1631. https://doi.org/10.1002/jper.19-0602
Shungin, D., Cornelis, M. C., Divaris, K., Holtfreter, B., Shaffer, J. R., Yu, Y. H., Barros, S. P., Beck, J. D., Biffar, R., Boerwinkle, E. A., Crout, R. J., Ganna, A., Hallmans, G., Hindy, G., Hu, F. B., Kraft, P., McNeil, D. W., Melander, O., Moss, K. L., … Franks, P. W. (2015). Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium. International Journal of Epidemiology, 44(2), 638-650. https://doi.org/10.1093/ije/dyv075
Shungin, D., Haworth, S., Divaris, K., Agler, C. S., Kamatani, Y., Keun Lee, M., Grinde, K., Hindy, G., Alaraudanjoki, V., Pesonen, P., Teumer, A., Holtfreter, B., Sakaue, S., Hirata, J., Yu, Y. H., Ridker, P. M., Giulianini, F., Chasman, D. I., Magnusson, P. K. E., … Johansson, I. (2019). Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data. Nature Communications, 10(1), 2773. https://doi.org/10.1038/s41467-019-10630-1
Slob, E. A., & Burgess, S. (2020). A comparison of robust Mendelian randomization methods using summary data. Genetic Epidemiology, 20, 1-17.
Söder, B., Jin, L. J., & Wickholm, S. (2002). Granulocyte elastase, matrix metalloproteinase-8 and prostaglandin E2 in gingival crevicular fluid in matched clinical sites in smokers and non-smokers with persistent periodontitis. Journal of Clinical Periodontology, 29(5), 384-391. https://doi.org/10.1034/j.1600-051x.2002.290502.x
Storey, J. D., & Tibshirani, R. (2003). Statistical significance for genomewide studies. Proceedings of the National Academy of Sciences, 100(16), 9440-9445.
Szabo, G., & Saha, B. (2015). Alcohol's effect on host defense. Alcohol Research: Current Reviews, 37(2), 159-170.
Wang, J., Lv, J., Wang, W., & Jiang, X. (2016). Alcohol consumption and risk of periodontitis: A meta-analysis. Journal of Clinical Periodontology, 43(7), 572-583. https://doi.org/10.1111/jcpe.12556
Wooldridge, J. M. (2010). Econometric analysis of cross section and panel data. MIT Press.
Wootton, R. E., Richmond, R. C., Stuijfzand, B. G., Lawn, R. B., Sallis, H. M., Taylor, G. M. J., Hemani, G., Jones, H. J., Zammit, S., Davey Smith, G., & Munafò, M. R. (2020). Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: A Mendelian randomisation study. Psychological Medicine, 50(14), 2435-2443. https://doi.org/10.1017/s0033291719002678
World Health Organization. (2013). Oral health surveys: Basic methods. World Health Organization.