Global Respiratory Syncytial Virus-Related Infant Community Deaths.
community death
lower respiratory tract infection
respiratory syncytial virus
Journal
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591
Titre abrégé: Clin Infect Dis
Pays: United States
ID NLM: 9203213
Informations de publication
Date de publication:
02 09 2021
02 09 2021
Historique:
entrez:
2
9
2021
pubmed:
3
9
2021
medline:
8
10
2021
Statut:
ppublish
Résumé
Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized. The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital. We studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8-3.3) was lower than in-hospital (2.4 months; IQR: 1.5-4.0; P < .0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P < 0.0001). We observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in-hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines.
Sections du résumé
BACKGROUND
Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized.
METHODS
The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital.
RESULTS
We studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8-3.3) was lower than in-hospital (2.4 months; IQR: 1.5-4.0; P < .0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P < 0.0001).
CONCLUSIONS
We observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in-hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines.
Identifiants
pubmed: 34472576
pii: 6362482
doi: 10.1093/cid/ciab528
pmc: PMC8411255
doi:
Substances chimiques
Respiratory Syncytial Virus Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
S229-S237Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : Bill and Melinda Gates Foundation
Investigateurs
Somsak Thamthitiwat
(S)
Angela Gentile
(A)
Maria Florencia Lucion
(MF)
Márcia Rosane Pires
(MR)
Fernanda de-Paris
(F)
Aubree Gordon
(A)
José Félix Sánchez
(JF)
Marilla G Lucero
(MG)
Socorro P Lupisan
(SP)
Bradford D Gessner
(BD)
Haoua Tall
(H)
Natasha Halasa
(N)
Najwa Khuri-Bulos
(N)
D James Nokes
(DJ)
Patrick K Munywoki
(PK)
Grieven P Otieno
(GP)
Katherine L O'Brien
(KL)
Katherine L Oshitani
(KL)
Maria Tereza da Costa Oliveira
(MT)
Carla Cecília de Freitas Lázaro Emediato
(CC)
Asad Ali
(A)
Uzma Bashir Aamir
(UB)
Daniel E Noyola
(DE)
Cheryl Cohen
(C)
Jocelyn Moyes
(J)
Heloisa Ihle Garcia Giamberardino
(HIG)
Jane Melissa Webler
(JM)
Patricia Gomes de Matos Bezerra
(PG)
Maria do Carmo Menezes Bezerra Duarte
(MDCM)
Helen Y Chu
(HY)
Rashmi Ranjan Das
(RR)
Martin W Weber
(MW)
Nusrat Homaira
(N)
Adam Jaffe
(A)
Katharine M Sturm-Ramirez
(KM)
Wei Su
(W)
Chiang Chun Yuan
(CC)
Sandra Chaves
(S)
Gideon O Emukule
(GO)
Sergio de Andrade Nishioka
(S)
Felipe Cotrim de Carvalho
(FC)
Şule Gökçe
(Ş)
Sonia M Raboni
(SM)
Michael Hawkes
(M)
Melina Messaoudi
(M)
Juliet Bryant
(J)
Ghassan S Dbaibo
(GS)
Rima Hanna-Wakim
(R)
J A A Sampath Jayaweera
(JAA)
Kirill Stolyarov
(K)
Piyarat Suntarattiwong
(P)
Tufária Mussá
(T)
Alfredo Bruno
(A)
Domenica de Mora
(D)
Nasamon Wanlapakorn
(N)
Zheng de Xie
(Z)
Junhong Ai
(J)
Jenny Ojeda
(J)
Lida Zamora
(L)
Evangeline Obodai
(E)
John Kofi Odoom
(JK)
Maha Talaat Ismail
(MT)
Andrea Buchwald
(A)
Cristina O'Callaghan-Gordo
(C)
Jaime Fernandez-Sarmiento
(J)
Evelyn Obando-Belalcazar
(E)
Tapan Dhole
(T)
Sheetal Verma
(S)
Aykut Eşki
(A)
G Ozturk Kartal
(G)
Mohammed Al Amad
(M)
Abdul Wahed Al Serouri
(AW)
Yoke FunChan
(Y)
Jamal I-Ching Sam
(JI)
Daniel Jarovsky
(D)
Daniella Gregória Bomfim Prado da Silva
(DGBP)
José Gareca Perales
(JG)
Teck-Hock Toh
(TH)
Jeffrey Lee Soon Yit
(JLS)
Tanil Kendirli
(T)
Emrah Gun
(E)
Tani Sagna
(T)
Serge Diagbouga
(S)
Fahmida Chowdhury
(F)
Md Ariful Islam
(MA)
Marietjie Venter
(M)
Adele Visser
(A)
Minh-Hong Pham
(MH)
Pablo Vásquez-Hoyos
(P)
Sebastián González-Dambrauskas
(S)
Franco Díaz Rubio
(FD)
Todd Karsies
(T)
Eliana Zemanate
(E)
Ledys Izquierdo
(L)
Rubén Lasso Palomino
(RL)
Rosalba Pardo-Carrero
(R)
Reginna Grigolli-Cesar
(R)
Soledad Menta
(S)
Nicolás Monteverde
(N)
Muhterem Duyu
(M)
Senjuti Saha
(S)
Samir K Saha
(SK)
Matthew Kelly
(M)
Marcela Echavarria
(M)
Tuan Tran
(T)
Aida Borgi
(A)
Ahmed Ayari
(A)
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.
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