Mutagenicity evaluation to UV filters of benzophenone-6, benzophenone-8, and 4-methylbenzylidene camphor by Ames test.
Animals
Benzophenones
/ toxicity
Biological Assay
Camphor
/ analogs & derivatives
Environmental Monitoring
/ methods
Humans
Microsomes, Liver
/ drug effects
Mutagenesis
/ drug effects
Mutagenicity Tests
/ methods
Rats
Salmonella typhimurium
/ drug effects
Sunscreening Agents
/ toxicity
Ultraviolet Rays
/ adverse effects
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
09
03
2021
accepted:
18
07
2021
entrez:
2
9
2021
pubmed:
3
9
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Benzophenone (BPs) and 4-Methylbenzylidene Camphor are used as ultraviolet (UV) filters to protect the skin and hair in personal care products. The discharging of the three chemicals may endanger the receiving water ecosystem. In the present study, the mutagenicity of BP-6, BP-8, and 4-Methylbenzylidene Camphor was tested using the Salmonella typhimurium reverse mutation test (Ames test) in the system with and without rat liver microsomal preparations (S9). Four S.typhimurium strains, TA97, TA98, TA100, and TA102 were employed in the Ames tests. The mutagenicity was detected from all three chemicals. The addition of S9 increased the mutation ratios of three chemicals to four strains, except BP-6 to TA100 strain and 4-MBC to TA97 and TA98 strain. In the mixed experiment, all positive effects were detected in the absence of S9. However, the results all became negative in the presence of S9. For the mixture of BP-6 and 4-MBC, positive results were detected on four tester strains except for the TA100 strain. For the mixture of BP-6, BP-8, and 4-MBC, positive results were detected on four strains. The mixture test results showed antagonism in mutagenicity for the mixture of BP-6 and 4-MBC to TA98 and TA100 strains and the mixture of BP-6, BP-8, and 4-MBC to TA100 and TA102 strains.
Identifiants
pubmed: 34473729
doi: 10.1371/journal.pone.0255504
pii: PONE-D-21-07858
pmc: PMC8412341
doi:
Substances chimiques
Benzophenones
0
Sunscreening Agents
0
Camphor
76-22-2
enzacamene
8I3XWY40L9
Types de publication
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0255504Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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