Predicting neonatal outcomes in infants with giant omphalocele using prenatal magnetic resonance imaging calculated observed-to-expected fetal lung volumes.
Female
Fetus
/ physiology
Gestational Age
Hernia, Umbilical
/ diagnosis
Humans
Infant, Newborn
Lung
/ growth & development
Lung Volume Measurements
/ instrumentation
Magnetic Resonance Imaging
/ methods
Nomograms
Noninvasive Prenatal Testing
/ methods
Pregnancy
Pregnancy Outcome
/ epidemiology
Retrospective Studies
Journal
Prenatal diagnosis
ISSN: 1097-0223
Titre abrégé: Prenat Diagn
Pays: England
ID NLM: 8106540
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
revised:
21
08
2021
received:
18
05
2021
accepted:
30
08
2021
pubmed:
3
9
2021
medline:
29
12
2021
entrez:
2
9
2021
Statut:
ppublish
Résumé
To examine the association between prenatal magnetic resonance imaging (MRI) based observed/expected total lung volume (O/E TLV) and outcome in neonates with giant omphalocele (GO). Between 06/2004 and 12/2019, 67 cases with isolated GO underwent prenatal and postnatal care at our institution. MRI-based O/E TLVs were calculated based on normative data from Meyers and from Rypens and correlated with postnatal survival and morbidities. O/E TLV scores were grouped based on severity into <25% (severe), between 25% and 50% (moderate), and >50% (mild) for risk stratification. O/E TLV was calculated for all patients according to Meyers nomograms and for 49 patients according to Rypens nomograms. Survival for GO neonates with severe, moderate, and mild pulmonary hypoplasia based on Meyers O/E TLV categories was 60%, 92%, and 96%, respectively (p = 0.04). There was a significant inverse association between Meyers O/E TLV and risk of neonatal morbidities (p < 0.05). A similar trend was observed with Rypens O/E TLV, but associations were less often significant likely related to the smaller sample size. Neonatal outcomes are related to fetal lung size in isolated GO. Assessment of Meyers O/E TLV allows identification of GO fetuses at greatest risk for complications secondary to pulmonary hypoplasia.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1439-1448Informations de copyright
© 2021 John Wiley & Sons Ltd.
Références
Danzer E, Gerdes M, D'Agostino JA, et al. Prospective, interdisciplinary follow-up of children with prenatally diagnosed giant omphalocele: short-term neurodevelopmental outcome. J Pediatr Surg. 2010;45:718-723.
Ein SH, Langer JC. Delayed management of giant omphalocele using silver sulfadiazine cream: an 18-year experience. J Pediatr Surg. 2012;47:494-500.
Danzer E, Victoria T, Bebbington MW, et al. Fetal MRI-calculated total lung volumes in the prediction of short-term outcome in giant omphalocele: preliminary findings. Fetal Diagn Ther. 2012;31:248-253.
Danzer E, Hedrick HL, Rintoul NE, Siegle J, Adzick NS, Panitch HB. Assessment of early pulmonary function abnormalities in giant omphalocele survivors. J Pediatr Surg. 2012;47:1811-1820.
Partridge EA, Hanna BD, Panitch HB, et al. Pulmonary hypertension in giant omphalocele infants. J Pediatr Surg. 2014;49:1767-1770.
Danzer E, Gerdes M, D'Agostino JA, et al. Patient characteristics are important determinants of neurodevelopmental outcome during infancy in giant omphalocele. Early Hum Dev. 2015;91:187-193.
Gorincour G, Bouvenot J, Mourot MG, et al. Prenatal prognosis of congenital diaphragmatic hernia using magnetic resonance imaging measurement of fetal lung volume. Ultrasound Obstet Gynecol. 2005;26:738-744.
Ruano R, Lazar DA, Cass DL, et al. Fetal lung volume and quantification of liver herniation by magnetic resonance imaging in isolated congenital diaphragmatic hernia. Ultrasound Obstet Gynecol. 2014;43:662-669.
Bebbington M, Victoria T, Danzer E, et al. Comparison of ultrasound and magnetic resonance imaging parameters in predicting survival in isolated left-sided congenital diaphragmatic hernia. Ultrasound Obstet Gynecol. 2014;43:670-674. doi:10.1002/uog.13271
Victoria T, Danzer E, Adzick NS. Use of ultrasound and MRI for evaluation of lung volumes in fetuses with isolated left congenital diaphragmatic hernia. Semin Pediatr Surg. 2013;22:30-36.
Victoria T, Bebbington MW, Danzer E, et al. Use of magnetic resonance imaging in prenatal prognosis of the fetus with isolated left congenital diaphragmatic hernia. Prenat Diagn. 2012;32:715-723.
Rypens F, Metens T, Rocourt N, et al. Fetal lung volume: estimation at MR imaging-initial results. Radiology. 2001;219:236-241.
Osada H, Kaku K, Masuda K, Iitsuka Y, Seki K, Sekiya S. Quantitative and qualitative evaluations of fetal lung with MR imaging. Radiology. 2004;231:887-892.
Duncan KR, Gowland PA, Moore RJ, Baker PN, Johnson IR. Assessment of fetal lung growth in utero with echo-planar MR imaging. Radiology. 1999;210:197-200.
Mahieu-Caputo D, Sonigo P, Dommergues M, et al. Fetal lung volume measurement by magnetic resonance imaging in congenital diaphragmatic hernia. BJOG. 2001;108:863-868.
Meyers ML, Garcia JR, Blough KL, Zhang W, Cassady CI, Mehollin-Ray AR. Fetal lung volumes by MRI: normal weekly values from 18 through 38 weeks' gestation. AJR Am J Roentgenol. 2018;211:432-438.
Hedrick HL, Danzer E, Merchant AM, et al. Liver position and lung-to-head ratio for prediction of extracorporeal membrane oxygenation and survival in isolated left congenital diaphragmatic hernia. Am J Obstet Gynecol. 2007;197:422 e421-424.
Akinkuotu AC, Sheikh F, Cass DL, et al. Are all pulmonary hypoplasias the same? A comparison of pulmonary outcomes in neonates with congenital diaphragmatic hernia, omphalocele and congenital lung malformation. J Pediatr Surg. 2015;50:55-59.
Haug S, St Peter S, Ramlogan S, et al. Impact of breast milk, respiratory insufficiency, and gastroesophageal reflux disease on enteral feeding in infants with omphalocele. J Pediatr Gastroenterol Nutr. 2019;68:e94-e98.
Argyle JC. Pulmonary hypoplasia in infants with giant abdominal wall defects. Pediatr Pathol. 1989;9:43-55.
Hershenson MB, Brouillette RT, Klemka L, Raffensperger JD, Poznanski AK, Hunt CE. Respiratory insufficiency in newborns with abdominal wall defects. J Pediatr Surg. 1985;20:348-353.
Griscom NT, Driscoll SG. Radiography of stillborn fetuses and infants dying at birth. AJR Am J Roentgenol. 1980;134:485-489.
Dimitriou G, Greenough A, Kavvadia V, et al. Diaphragmatic function in infants with surgically corrected anomalies. Pediatr Res. 2003;54:502-508.
Kamata S, Usui N, Sawai T, Nose K, Fukuzawa M. Prenatal detection of pulmonary hypoplasia in giant omphalocele. Pediatr Surg Int. 2008;24:107-111.
Prendergast M, Rafferty GF, Davenport M, et al. Three-dimensional ultrasound fetal lung volumes and infant respiratory outcome: a prospective observational study. BJOG. 2011;118:608-614.
Cannie MM, Jani JC, Van Kerkhove FV, et al. Fetal body volume at MR imaging to quantify total fetal lung volume: normal ranges. Radiology. 2008;247:197-203.