Impact of the Difluoromethylene Group in the Organocatalyzed Acylative Kinetic Resolution of α,α-Difluorohydrins.
acylation
alcohols
difluoromethylene group
isothiourea
organocatalysis
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
15 11 2021
15 11 2021
Historique:
received:
26
05
2021
pubmed:
3
9
2021
medline:
3
9
2021
entrez:
2
9
2021
Statut:
ppublish
Résumé
Due to the omnipresence of chiral organofluorine compounds in pharmaceutical, agrochemical, and material chemistry, the development of enantioselective methods for their preparation is highly desirable. In the present study, the enantioselective organocatalyzed acylation of α,α-difluorohydrins using a commercially available chiral isothiourea is reported through a kinetic resolution (KR) process. It reveals that the difluoromethylene moiety (C(sp
Identifiants
pubmed: 34473886
doi: 10.1002/anie.202107041
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
24924-24929Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-18-CE07-0036
Informations de copyright
© 2021 Wiley-VCH GmbH.
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Deposition Number 2072813 contains the supplementary crystallographic data for this paper. These data are provided free of charge by the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum Karlsruhe Access Structures service www.ccdc.cam.ac.uk/structures.