Interferon gamma protective against Sarcocystis neurona encephalitis in susceptible murine model.
Equine protozoal myeloencephalitis
Horse
Interferon gamma
Opossum
Sarcocystis neurona
Journal
Veterinary immunology and immunopathology
ISSN: 1873-2534
Titre abrégé: Vet Immunol Immunopathol
Pays: Netherlands
ID NLM: 8002006
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
01
03
2021
revised:
30
07
2021
accepted:
26
08
2021
pubmed:
3
9
2021
medline:
12
2
2022
entrez:
2
9
2021
Statut:
ppublish
Résumé
Sarcocystis neurona is the predominant etiological agent of the infectious equine neurologic disease, equine protozoal myeloencephalitis (EPM), which is prevalent in the United States. A wealth of knowledge about S. neurona biology and its life cycle has accumulated over the last several decades. However, much remains unknown about the aberrant equine host's immune response to S. neurona and the relatively high prevalence of exposure to the protozoa but relatively infrequent occurrence of clinical neurologic disease. Mouse models simulating EPM are commonly used to study the disease due to numerous challenges associated with studying the disease in horses. The critical role of the cytokine, interferon gamma (IFNγ), in protection against S. neurona encephalitis has been well established as Ifnγ
Identifiants
pubmed: 34474260
pii: S0165-2427(21)00137-9
doi: 10.1016/j.vetimm.2021.110319
pii:
doi:
Substances chimiques
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110319Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.