Frailty Can Predict Prognosis After Hepatectomy in Patients With Colorectal Liver Metastasis.
Adult
Aged
Aged, 80 and over
Colorectal Neoplasms
/ drug therapy
Drug Therapy
Female
Frailty
/ complications
Hepatectomy
/ methods
Humans
Liver Neoplasms
/ drug therapy
Male
Middle Aged
Multivariate Analysis
Neoplasm Recurrence, Local
/ epidemiology
Prognosis
Retrospective Studies
Survival Analysis
Treatment Outcome
Colorectal cancer
frailty
hepatectomy
liver metastasis
overall survival
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
21
04
2021
revised:
25
07
2021
accepted:
26
07
2021
entrez:
3
9
2021
pubmed:
4
9
2021
medline:
11
9
2021
Statut:
ppublish
Résumé
The aim of this study was to investigate frailty as a prognostic factor in patients with colorectal liver metastasis undergoing hepatectomy. Eighty-seven patients who underwent hepatectomy at our institution were enrolled. Frailty was defined as a score of ≥4 on a clinical frailty scale. Patients were divided into frailty (n=29) and non-frailty (n=58) groups. Overall and cancer-specific survival rates were significantly worse in the frailty group compared with the non-frailty group, and multivariate analysis revealed frailty as an independent prognostic factor. Disease-free survival tended to be worse in the frailty group. Fifty-eight patients relapsed after the first hepatectomy. Twenty-one of 58 recurrent patients were allocated to the frailty group. After recurrence, chemotherapy was significantly more frequently performed in the non-frailty group compared with the frailty group. Frailty can predict the prognosis of patients with colorectal liver metastasis undergoing hepatectomy.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
The aim of this study was to investigate frailty as a prognostic factor in patients with colorectal liver metastasis undergoing hepatectomy.
PATIENTS AND METHODS
METHODS
Eighty-seven patients who underwent hepatectomy at our institution were enrolled. Frailty was defined as a score of ≥4 on a clinical frailty scale. Patients were divided into frailty (n=29) and non-frailty (n=58) groups.
RESULTS
RESULTS
Overall and cancer-specific survival rates were significantly worse in the frailty group compared with the non-frailty group, and multivariate analysis revealed frailty as an independent prognostic factor. Disease-free survival tended to be worse in the frailty group. Fifty-eight patients relapsed after the first hepatectomy. Twenty-one of 58 recurrent patients were allocated to the frailty group. After recurrence, chemotherapy was significantly more frequently performed in the non-frailty group compared with the frailty group.
CONCLUSION
CONCLUSIONS
Frailty can predict the prognosis of patients with colorectal liver metastasis undergoing hepatectomy.
Identifiants
pubmed: 34475092
pii: 41/9/4637
doi: 10.21873/anticanres.15277
doi:
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4637-4644Informations de copyright
Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.