A Clinical PET Imaging Tracer ([
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
01 12 2021
01 12 2021
Historique:
received:
10
02
2021
revised:
15
07
2021
accepted:
30
08
2021
pubmed:
4
9
2021
medline:
8
4
2022
entrez:
3
9
2021
Statut:
ppublish
Résumé
Pyruvate kinase M2 (PKM2) catalyzes the final step in glycolysis, a key process of cancer metabolism. PKM2 is preferentially expressed by glioblastoma (GBM) cells with minimal expression in healthy brain. We describe the development, validation, and translation of a novel PET tracer to study PKM2 in GBM. We evaluated 1-((2-fluoro-6-[ [ In mouse imaging studies, [ We developed and translated [
Identifiants
pubmed: 34475101
pii: 1078-0432.CCR-21-0544
doi: 10.1158/1078-0432.CCR-21-0544
pmc: PMC8639752
mid: NIHMS1738932
doi:
Substances chimiques
Diazonium Compounds
0
Sulfanilic Acids
0
Pyruvate Kinase
EC 2.7.1.40
diazobenzenesulfonic acid
Z0105S98AO
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6467-6478Subventions
Organisme : NCI NIH HHS
ID : R01 CA216054
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
©2021 American Association for Cancer Research.
Références
Nat Rev Cancer. 2002 Sep;2(9):683-93
pubmed: 12209157
Neuro Oncol. 2015 Sep;17(9):1188-98
pubmed: 26250565
Cell Biosci. 2019 Jun 26;9:52
pubmed: 31391918
Mol Imaging Biol. 2017 Oct;19(5):665-672
pubmed: 28236227
Nature. 2008 Mar 13;452(7184):230-3
pubmed: 18337823
J Med Chem. 2012 Oct 11;55(19):8272-8282
pubmed: 22853801
Neuro Oncol. 2016 Feb;18(2):160-72
pubmed: 26180081
Clin Cancer Res. 2005 Apr 15;11(8):2785-808
pubmed: 15837727
Radiology. 2015 Nov;277(2):497-506
pubmed: 25965900
Bioengineering (Basel). 2018 Nov 28;5(4):
pubmed: 30487391
J Neurooncol. 2018 Sep;139(2):399-409
pubmed: 29679199
J Nucl Med. 2007 Sep;48(9):1468-81
pubmed: 17704239
Neuro Oncol. 2018 Sep 3;20(10):1400-1410
pubmed: 29590461
Neuro Oncol. 2016 Sep;18(9):1199-208
pubmed: 27106405
Nat Chem Biol. 2012 Oct;8(10):839-47
pubmed: 22922757
Glia. 2014 Jul;62(7):1125-41
pubmed: 24692237
J Exp Clin Cancer Res. 2019 May 23;38(1):218
pubmed: 31122265
Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11402-11407
pubmed: 31123153
Eur J Nucl Med Mol Imaging. 2020 Aug;47(9):2123-2130
pubmed: 31938892
Radiology. 2011 Jul;260(1):182-91
pubmed: 21502381
Cancer Res. 2014 Dec 1;74(23):7115-24
pubmed: 25320009
Mol Imaging Biol. 2018 Dec;20(6):1015-1024
pubmed: 29736561
Clinics (Sao Paulo). 2011;66 Suppl 1:33-43
pubmed: 21779721
Eur J Nucl Med Mol Imaging. 2019 Mar;46(3):558-568
pubmed: 30612162
Anal Chem. 2009 Apr 1;81(7):2779-84
pubmed: 19281170
Sci Transl Med. 2015 Oct 21;7(310):310ra169
pubmed: 26491079
Neuro Oncol. 2019 Nov 1;21(Suppl 5):v1-v100
pubmed: 31675094
PLoS One. 2015 Oct 26;10(10):e0141153
pubmed: 26502297
J Nucl Med. 2001 May;42(5 Suppl):1S-93S
pubmed: 11483694
Mol Imaging Biol. 2020 Feb;22(1):124-133
pubmed: 30989436
Oncol Lett. 2016 Mar;11(3):1980-1986
pubmed: 26998110
Neuro Oncol. 2013 Aug;15(8):1058-67
pubmed: 23460322
PLoS One. 2013;8(2):e57610
pubmed: 23451252
J Nucl Med. 2006 Jun;47(6):904-11
pubmed: 16741298
Cell. 2013 Oct 10;155(2):397-409
pubmed: 24120138
Neural Regen Res. 2015 Oct;10(10):1570-1
pubmed: 26692843
J Nucl Med. 1999 Jan;40(1):205-12
pubmed: 9935078
Eur J Nucl Med. 2000 May;27(5):542-9
pubmed: 10853810
J Korean Neurosurg Soc. 2014 Jan;55(1):5-11
pubmed: 24570811
Front Oncol. 2020 Mar 02;10:159
pubmed: 32195169
Eur J Nucl Med Mol Imaging. 2003 Apr;30(4):519-24
pubmed: 12589478
Curr Opin Neurol. 2009 Dec;22(6):633-8
pubmed: 19770760
Front Neurol. 2019 May 07;10:460
pubmed: 31133966
J Neurosci Res. 2001 Dec 1;66(5):839-43
pubmed: 11746409
Science. 2006 May 26;312(5777):1168-71
pubmed: 16728630
PET Clin. 2014 Apr;9(2):129-40
pubmed: 24772054