Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.

Blood Proteins / genetics Gene Expression Regulation / genetics Genome-Wide Association Study Humans Multifactorial Inheritance / genetics Polymorphism, Single Nucleotide / genetics Quantitative Trait Loci / genetics Transcriptome / genetics

Journal

Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904

Informations de publication

Date de publication:
09 2021
Historique:
received: 20 05 2020
accepted: 12 07 2021
pubmed: 4 9 2021
medline: 15 10 2021
entrez: 3 9 2021
Statut: ppublish

Résumé

Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms on the transcriptome. To investigate the genetics of gene expression, we performed cis- and trans-expression quantitative trait locus (eQTL) analyses using blood-derived expression from 31,684 individuals through the eQTLGen Consortium. We detected cis-eQTL for 88% of genes, and these were replicable in numerous tissues. Distal trans-eQTL (detected for 37% of 10,317 trait-associated variants tested) showed lower replication rates, partially due to low replication power and confounding by cell type composition. However, replication analyses in single-cell RNA-seq data prioritized intracellular trans-eQTL. Trans-eQTL exerted their effects via several mechanisms, primarily through regulation by transcription factors. Expression of 13% of the genes correlated with polygenic scores for 1,263 phenotypes, pinpointing potential drivers for those traits. In summary, this work represents a large eQTL resource, and its results serve as a starting point for in-depth interpretation of complex phenotypes.

Identifiants

DOI: 10.1038/s41588-021-00913-z PMID: 34475573 PMC: PMC8432599
pubmed: 34475573
doi: 10.1038/s41588-021-00913-z
pii: 10.1038/s41588-021-00913-z
pmc: PMC8432599
mid: NIHMS1723987
doi:

Substances chimiques

Blood Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1300-1310

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH109905
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES023834
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES020506
Pays : United States
Organisme : Wellcome Trust
ID : 201488/Z/16/Z
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA107431
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES024834
Pays : United States
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : R35 ES028379
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH101814
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM108711
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG008150
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL105756
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_15018
Pays : United Kingdom

Investigateurs

Peter A C 't Hoen (PAC)
Joyce van Meurs (J)
Jenny van Dongen (J)
Maarten van Iterson (M)
Morris A Swertz (MA)
Marc Jan Bonder (M)

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Auteurs

Urmo Võsa (U)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. urmo.vosa@gmail.com.
Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. urmo.vosa@gmail.com.
ORCID: 0000-0003-3476-1652

Annique Claringbould (A)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. anniqueclaringbould@gmail.com.
Oncode Institute, Amsterdam, the Netherlands. anniqueclaringbould@gmail.com.
Structural & Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. anniqueclaringbould@gmail.com.
ORCID: 0000-0002-9201-6557

Harm-Jan Westra (HJ)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Oncode Institute, Amsterdam, the Netherlands.
ORCID: 0000-0001-7038-567X

Marc Jan Bonder (MJ)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.

Patrick Deelen (P)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Oncode Institute, Amsterdam, the Netherlands.
Genomics Coordination Center, University Medical Centre Groningen, Groningen, the Netherlands.
Department of Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands.
ORCID: 0000-0002-5654-3966

Biao Zeng (B)

School of Biological Sciences, Georgia Tech, Atlanta, GA, USA.

Holger Kirsten (H)

Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
ORCID: 0000-0002-3126-7950

Ashis Saha (A)

Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA.

Roman Kreuzhuber (R)

Department of Haematology, University of Cambridge, Cambridge, United Kingdom.
NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.
European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.

Seyhan Yazar (S)

Garvan Institute of Medical Research, Garvan-Weizmann Centre for Cellular Genomics, Sydney, New South Wales, Australia.

Harm Brugge (H)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Oncode Institute, Amsterdam, the Netherlands.

Roy Oelen (R)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Oncode Institute, Amsterdam, the Netherlands.
ORCID: 0000-0002-5026-6531

Dylan H de Vries (DH)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Oncode Institute, Amsterdam, the Netherlands.
ORCID: 0000-0002-0953-0257

Monique G P van der Wijst (MGP)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Oncode Institute, Amsterdam, the Netherlands.

Silva Kasela (S)

Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.

Natalia Pervjakova (N)

Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.

Isabel Alves (I)

Computational Biology, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
L'institut du thorax, Université de Nantes, CHU Nantes, INSERM, CNRS, Nantes, France.
ORCID: 0000-0002-4303-5479

Marie-Julie Favé (MJ)

Computational Biology, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.

Mawussé Agbessi (M)

Computational Biology, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.

Mark W Christiansen (MW)

Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.

Rick Jansen (R)

Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute and Amsterdam Neuroscience, Amsterdam, the Netherlands.
ORCID: 0000-0002-3333-6737

Ilkka Seppälä (I)

Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Lin Tong (L)

Department of Public Health Sciences, University of Chicago, Chicago, IL, USA.

Alexander Teumer (A)

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.
ORCID: 0000-0002-8309-094X

Katharina Schramm (K)

Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Department of Medicine I, University Hospital Munich, Ludwig Maximilian's University, Munich, Germany.

Gibran Hemani (G)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.

Joost Verlouw (J)

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
ORCID: 0000-0003-2373-0981

Hanieh Yaghootkar (H)

Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, United Kingdom.
School of Life Sciences, College of Liberal Arts and Science, University of Westminster, London, United Kingdom.
Division of Medical Sciences, Department of Health Sciences, Luleå University of Technology, Luleå, Sweden.

Reyhan Sönmez Flitman (R)

Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Swiss Institute of Bioinformatics, Lausanne, Switzerland.

Andrew Brown (A)

Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
Population Health and Genomics, University of Dundee, Dundee, United Kingdom.
ORCID: 0000-0002-8087-3033

Viktorija Kukushkina (V)

Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.

Anette Kalnapenkis (A)

Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.

Sina Rüeger (S)

Lausanne University Hospital, Lausanne, Switzerland.
ORCID: 0000-0003-2848-9242

Eleonora Porcu (E)

Lausanne University Hospital, Lausanne, Switzerland.
ORCID: 0000-0003-2878-7485

Jaanika Kronberg (J)

Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.

Johannes Kettunen (J)

Computational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland.
Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
Biocenter Oulu, University of Oulu, Oulu, Finland.
Finnish Institute for Health and Welfare, Helsinki, Finland.
ORCID: 0000-0002-3345-491X

Bernett Lee (B)

Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.

Futao Zhang (F)

Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.

Ting Qi (T)

Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.

Jose Alquicira Hernandez (JA)

Garvan Institute of Medical Research, Garvan-Weizmann Centre for Cellular Genomics, Sydney, New South Wales, Australia.
ORCID: 0000-0002-9049-7780

Wibowo Arindrarto (W)

Leiden University Medical Center, Leiden, the Netherlands.

Frank Beutner (F)

Heart Center Leipzig, Universität Leipzig, Leipzig, Germany.

Julia Dmitrieva (J)

Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.

Mahmoud Elansary (M)

Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.

Benjamin P Fairfax (BP)

Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
ORCID: 0000-0001-7413-5002

Michel Georges (M)

Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
ORCID: 0000-0003-4124-2375

Bastiaan T Heijmans (BT)

Leiden University Medical Center, Leiden, the Netherlands.
ORCID: 0000-0001-5918-0534

Alex W Hewitt (AW)

Menzies Institute for Medical Research, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
Centre for Eye Research Australia, Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia.
ORCID: 0000-0002-5123-5999

Mika Kähönen (M)

Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Yungil Kim (Y)

Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA.
Genetics and Genomic Science Department, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Julian C Knight (JC)

Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
ORCID: 0000-0002-0377-5536

Peter Kovacs (P)

IFB Adiposity Diseases, Universität Leipzig, Leipzig, Germany.
ORCID: 0000-0002-0290-5423

Knut Krohn (K)

Interdisciplinary Center for Clinical Research, Faculty of Medicine, Universität Leipzig, Leipzig, Germany.
ORCID: 0000-0001-8110-1273

Shuang Li (S)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Genomics Coordination Center, University Medical Centre Groningen, Groningen, the Netherlands.
ORCID: 0000-0002-6634-4856

Markus Loeffler (M)

Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.

Urko M Marigorta (UM)

School of Biological Sciences, Georgia Tech, Atlanta, GA, USA.
Integrative Genomics Lab, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bizkaia Science and Technology Park, Derio, Spain.
IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.

Hailang Mei (H)

Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands.

Yukihide Momozawa (Y)

Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.

Martina Müller-Nurasyid (M)

Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Department of Medicine I, University Hospital Munich, Ludwig Maximilian's University, Munich, Germany.
IBE, Faculty of Medicine, LMU Munich, Munich, Germany.
ORCID: 0000-0003-3793-5910

Matthias Nauck (M)

DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
ORCID: 0000-0002-6678-7964

Michel G Nivard (MG)

Department of Biological Psychology, Faculty of Behaviour and Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands.
ORCID: 0000-0003-2015-1888

Brenda W J H Penninx (BWJH)

Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute and Amsterdam Neuroscience, Amsterdam, the Netherlands.

Jonathan K Pritchard (JK)

Department of Biology, Stanford University, Stanford, CA, USA.
Department of Genetics, Stanford University, Stanford, CA, USA.
ORCID: 0000-0002-8828-5236

Olli T Raitakari (OT)

Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.

Olaf Rotzschke (O)

Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.

Eline P Slagboom (EP)

Leiden University Medical Center, Leiden, the Netherlands.
ORCID: 0000-0002-2875-4723

Coen D A Stehouwer (CDA)

Department of Internal Medicine and School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center, Maastricht, the Netherlands.

Michael Stumvoll (M)

Department of Medicine, Universität Leipzig, Leipzig, Germany.

Patrick Sullivan (P)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Peter A C 't Hoen (PAC)

Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands.
ORCID: 0000-0003-4450-3112

Joachim Thiery (J)

LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Institute for Laboratory Medicine, LIFE-Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany.

Anke Tönjes (A)

Department of Medicine, Universität Leipzig, Leipzig, Germany.

Jenny van Dongen (J)

Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute and Amsterdam Neuroscience, Amsterdam, the Netherlands.
ORCID: 0000-0003-2063-8741

Maarten van Iterson (M)

Leiden University Medical Center, Leiden, the Netherlands.

Jan H Veldink (JH)

UMC Utrecht Brain Center, University Medical Center Utrecht, Department of Neurology, Utrecht University, Utrecht, the Netherlands.
ORCID: 0000-0001-5572-9657

Uwe Völker (U)

Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
ORCID: 0000-0002-5689-3448

Robert Warmerdam (R)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Oncode Institute, Amsterdam, the Netherlands.
ORCID: 0000-0001-8691-0053

Cisca Wijmenga (C)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
ORCID: 0000-0002-5635-1614

Morris Swertz (M)

Genomics Coordination Center, University Medical Centre Groningen, Groningen, the Netherlands.
ORCID: 0000-0002-0979-3401

Anand Andiappan (A)

Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
ORCID: 0000-0002-8442-1544

Grant W Montgomery (GW)

Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
ORCID: 0000-0002-4140-8139

Samuli Ripatti (S)

Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0002-0504-1202

Markus Perola (M)

National Institute for Health and Welfare, University of Helsinki, Helsinki, Finland.

Zoltan Kutalik (Z)

Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.

Emmanouil Dermitzakis (E)

Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland.
ORCID: 0000-0002-9302-6490

Sven Bergmann (S)

Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Swiss Institute of Bioinformatics, Lausanne, Switzerland.
ORCID: 0000-0002-6785-9034

Timothy Frayling (T)

Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, United Kingdom.
ORCID: 0000-0001-8362-2603

Joyce van Meurs (J)

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.

Holger Prokisch (H)

Institute of Neurogenomics, Helmholtz Zentrum München, Neuherberg, Germany.
Institute of Human Genetics, Technical University Munich, Munich, Germany.
ORCID: 0000-0003-2379-6286

Habibul Ahsan (H)

Department of Public Health Sciences, University of Chicago, Chicago, IL, USA.

Brandon L Pierce (BL)

Department of Public Health Sciences, University of Chicago, Chicago, IL, USA.

Terho Lehtimäki (T)

Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Dorret I Boomsma (DI)

Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute and Amsterdam Neuroscience, Amsterdam, the Netherlands.
ORCID: 0000-0002-7099-7972

Bruce M Psaty (BM)

Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.
ORCID: 0000-0002-7278-2190

Sina A Gharib (SA)

Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Department of Medicine, University of Washington, Seattle, WA, USA.
ORCID: 0000-0002-2480-4367

Philip Awadalla (P)

Computational Biology, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.

Lili Milani (L)

Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
ORCID: 0000-0002-5323-3102

Willem H Ouwehand (WH)

Department of Haematology, University of Cambridge, Cambridge, United Kingdom.
NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
ORCID: 0000-0002-7744-1790

Kate Downes (K)

Department of Haematology, University of Cambridge, Cambridge, United Kingdom.
NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.

Oliver Stegle (O)

Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Division of Computational Genomics and Systems Genetics, German Cancer Research Center, Heidelberg, Germany.
ORCID: 0000-0002-8818-7193

Alexis Battle (A)

Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA.
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.

Peter M Visscher (PM)

Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
ORCID: 0000-0002-2143-8760

Jian Yang (J)

Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
School of Life Sciences, Westlake University, Hangzhou, China.
Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
ORCID: 0000-0003-2001-2474

Markus Scholz (M)

Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
ORCID: 0000-0002-4059-1779

Joseph Powell (J)

Garvan Institute of Medical Research, Garvan-Weizmann Centre for Cellular Genomics, Sydney, New South Wales, Australia.
UNSW Cellular Genomics Futures Institute, University of New South Wales, Sydney, New South Wales, Australia.

Greg Gibson (G)

School of Biological Sciences, Georgia Tech, Atlanta, GA, USA.
ORCID: 0000-0002-5352-5877

Tõnu Esko (T)

Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
ORCID: 0000-0003-1982-6569

Lude Franke (L)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. lude@ludesign.nl.
Oncode Institute, Amsterdam, the Netherlands. lude@ludesign.nl.
ORCID: 0000-0002-5159-8802

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Large-scale cis- and trans-eQTL analyses...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Large-scale cis- and trans-eQTL analyses...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Large-scale cis- and trans-eQTL analyses...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Large-scale cis- and trans-eQTL analyses...
questionsmedicales.fr › Phénomènes génétiques › Modes de transmission héréditaire › Hérédité multifactorielle › Large-scale cis- and trans-eQTL analyses...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Large-scale cis- and trans-eQTL analyses...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Locus de caractère quantitatif › Large-scale cis- and trans-eQTL analyses...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Large-scale cis- and trans-eQTL analyses...