Increased Endogenous GDNF in Mice Protects Against Age-Related Decline in Neuronal Cholinergic Markers.

acetylcholinesterase (AChE) aging brain choline acetyltransferase (ChAT) cholinergic index cholinergic markers glial cell line-derived neurotrophic factor (GDNF) nerve growth factor (NGF)

Journal

Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824

Informations de publication

Date de publication:
2021
Historique:
received: 24 05 2021
accepted: 14 07 2021
entrez: 3 9 2021
pubmed: 4 9 2021
medline: 4 9 2021
Statut: epublish

Résumé

Gradual decline in cholinergic transmission and cognitive function occurs during normal aging, whereas pathological loss of cholinergic function is a hallmark of different types of dementia, including Alzheimer's disease (AD), Lewy body dementia (LBD), and Parkinson's disease dementia (PDD). Glial cell line-derived neurotrophic factor (GDNF) is known to modulate and enhance the dopamine system. However, how endogenous GDNF influences brain cholinergic transmission has remained elusive. In this study, we explored the effect of a twofold increase in endogenous GDNF (Gdnf hypermorphic mice,

Identifiants

DOI: 10.3389/fnagi.2021.714186 PMID: 34475820 PMC: PMC8406776
pubmed: 34475820
doi: 10.3389/fnagi.2021.714186
pmc: PMC8406776
doi:

Types de publication

Journal Article

Langues

eng

Pagination

714186

Informations de copyright

Copyright © 2021 Mitra, Turconi, Darreh-Shori, Mätlik, Aquilino, Eriksdotter and Andressoo.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Sumonto Mitra (S)

Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, Sweden.

Giorgio Turconi (G)

Department of Pharmacology, Faculty of Medicine and Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

Taher Darreh-Shori (T)

Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, Sweden.

Kärt Mätlik (K)

Department of Pharmacology, Faculty of Medicine and Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

Matilde Aquilino (M)

Department of Pharmacology, Faculty of Medicine and Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

Maria Eriksdotter (M)

Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, Sweden.
Theme Inflammation and Aging, Karolinska University Hospital, Huddinge, Sweden.

Jaan-Olle Andressoo (JO)

Department of Pharmacology, Faculty of Medicine and Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.

Classifications MeSH