The differential expression of perilipin-2 in hepatoblastoma and its association with prognosis.
Journal
Histology and histopathology
ISSN: 1699-5848
Titre abrégé: Histol Histopathol
Pays: Spain
ID NLM: 8609357
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
pubmed:
4
9
2021
medline:
1
4
2022
entrez:
3
9
2021
Statut:
ppublish
Résumé
Perilipin-2, a lipid droplet (LD) coating protein, has been found to be involved in cancer progression. However, its role in hepatoblastoma (HB) is undefined. We collected 87 HB samples and the corresponding clinical data. Immunohistochemistry (IHC) staining was performed to detect perilipin-2 and the association of the perilipin-2 expression with clinical characteristics and prognosis was analyzed. The expression of perilipin-2 was increased in fetal HB components in comparison to embryonal HB components. The predominant staining pattern was vesicular in fetal HB cells, while it was granular in embryonal HB cells. Furthermore, strong expression of perilipin-2 was associated with the histopathological type of fetal predominant HB. Although event-free survival (EFS) did not differ to a statistically significant extent between the strong and weak expression groups in a univariate survival analysis, a multivariate survival analysis revealed that EFS was significantly improved in the strong perilipin-2 expression group. In conclusion, perilipin-2 is differentially expressed in HB and the strong expression of perilipin-2 predicts a better prognosis.
Identifiants
pubmed: 34477212
pii: HH-18-371
doi: 10.14670/HH-18-371
doi:
Substances chimiques
Perilipin-2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1169-1178Subventions
Organisme : Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan
ID : 19K16783
Organisme : Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan
ID : 20K07454
Organisme : Promoted Research from Kanazawa Medical University
ID : S2018-6
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