gp130 Cytokines Activate Novel Signaling Pathways and Alter Bone Dissemination in ER+ Breast Cancer Cells.
CANCER
CYTOKINES CELL/TISSUE SIGNALING-ENDOCRINE PATHWAYS
OTHER CELL/TISSUE SIGNALING-PARACRINE PATHWAYS
TUMOR-INDUCED BONE DISEASE
Journal
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
ISSN: 1523-4681
Titre abrégé: J Bone Miner Res
Pays: United States
ID NLM: 8610640
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
09
08
2021
received:
07
01
2021
accepted:
29
08
2021
pubmed:
4
9
2021
medline:
15
3
2022
entrez:
3
9
2021
Statut:
ppublish
Résumé
Breast cancer cells frequently home to the bone marrow, where they encounter signals that promote survival and quiescence or stimulate their proliferation. The interleukin-6 (IL-6) cytokines signal through the co-receptor glycoprotein130 (gp130) and are abundantly secreted within the bone microenvironment. Breast cancer cell expression of leukemia inhibitory factor (LIF) receptor (LIFR)/STAT3 signaling promotes tumor dormancy in the bone, but it is unclear which, if any of the cytokines that signal through LIFR, including LIF, oncostatin M (OSM), and ciliary neurotrophic factor (CNTF), promote tumor dormancy and which signaling pathways are induced. We first confirmed that LIF, OSM, and CNTF and their receptor components were expressed across a panel of breast cancer cell lines, although expression was lower in estrogen receptor-negative (ER
Identifiants
pubmed: 34477239
doi: 10.1002/jbmr.4430
pmc: PMC8828687
mid: NIHMS1737666
doi:
Substances chimiques
Cytokines
0
IL6ST protein, human
0
Interleukin-6
0
Receptors, Cytokine
0
Receptors, OSM-LIF
0
Cytokine Receptor gp130
133483-10-0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
185-201Subventions
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NCI NIH HHS
ID : R00CA194198
Pays : United States
Organisme : NIH HHS
ID : P30CA068485
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA068485
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA194198
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA221675
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002243
Pays : United States
Informations de copyright
© 2021 American Society for Bone and Mineral Research (ASBMR).
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