Ruthenium(II) Diphosphine Complexes with Mercapto Ligands That Inhibit Topoisomerase IB and Suppress Tumor Growth In Vivo.

Antineoplastic Agents / chemical synthesis Cell Proliferation / drug effects Coordination Complexes / chemical synthesis DNA Topoisomerases, Type I / metabolism Drug Screening Assays, Antitumor Humans Ligands Phosphines / chemistry Ruthenium / chemistry Topoisomerase I Inhibitors / chemical synthesis Tumor Cells, Cultured

Journal

Inorganic chemistry
ISSN: 1520-510X
Titre abrégé: Inorg Chem
Pays: United States
ID NLM: 0366543

Informations de publication

Date de publication:
20 Sep 2021
Historique:
pubmed: 4 9 2021
medline: 21 10 2021
entrez: 3 9 2021
Statut: ppublish

Résumé

Ruthenium(II) complexes (

Identifiants

DOI: 10.1021/acs.inorgchem.1c01539 PMID: 34477373
pubmed: 34477373
doi: 10.1021/acs.inorgchem.1c01539
doi:

Substances chimiques

Antineoplastic Agents 0
Coordination Complexes 0
Ligands 0
Phosphines 0
Topoisomerase I Inhibitors 0
Ruthenium 7UI0TKC3U5
DNA Topoisomerases, Type I EC 5.99.1.2
TOP1 protein, human EC 5.99.1.2
phosphine FW6947296I

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

14174-14189

Auteurs

Monize M da Silva (MM)

Departamento de Química, Universidade Federal de São Carlos, CP 676, CEP 13565-905 São Carlos, São Paulo, Brazil.

Gabriel H Ribeiro (GH)

Departamento de Química, Universidade Federal de São Carlos, CP 676, CEP 13565-905 São Carlos, São Paulo, Brazil.
ORCID: 0000-0003-0738-1638

Mariana S de Camargo (MS)

Departamento de Química, Universidade Federal de São Carlos, CP 676, CEP 13565-905 São Carlos, São Paulo, Brazil.

Antônio G Ferreira (AG)

Departamento de Química, Universidade Federal de São Carlos, CP 676, CEP 13565-905 São Carlos, São Paulo, Brazil.

Leandro Ribeiro (L)

Departamento de Química, Universidade Federal de São Carlos, CP 676, CEP 13565-905 São Carlos, São Paulo, Brazil.

Marília I F Barbosa (MIF)

Departamento de Química, Universidade Federal de São Carlos, CP 676, CEP 13565-905 São Carlos, São Paulo, Brazil.

Victor M Deflon (VM)

Instituto de Química de São Carlos, Universidade de São Paulo, CEP 13565-905 São Carlos, São Paulo, Brazil.
ORCID: 0000-0002-5368-6486

Silvia Castelli (S)

Dipartimento di Biologia, Università Tor Vergata di Roma, 00133 Rome, Italy.

Alessandro Desideri (A)

Dipartimento di Biologia, Università Tor Vergata di Roma, 00133 Rome, Italy.

Rodrigo S Corrêa (RS)

Departamento de Química, Universidade Federal de Ouro Preto, CEP 35400-000 Ouro Preto, Minas Gerais, Brazil.

Arthur B Ribeiro (AB)

Universidade de Franca, CEP 14404-600, Franca, São Paulo, Brazil.
ORCID: 0000-0002-4056-9571

Heloiza D Nicolella (HD)

Universidade de Franca, CEP 14404-600, Franca, São Paulo, Brazil.

Saulo D Ozelin (SD)

Universidade de Franca, CEP 14404-600, Franca, São Paulo, Brazil.
ORCID: 0000-0003-1769-4347

Denise C Tavares (DC)

Universidade de Franca, CEP 14404-600, Franca, São Paulo, Brazil.
ORCID: 0000-0003-4646-5914

Alzir A Batista (AA)

Departamento de Química, Universidade Federal de São Carlos, CP 676, CEP 13565-905 São Carlos, São Paulo, Brazil.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Ruthenium(II) Diphosphine Complexes with...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Ruthenium(II) Diphosphine Complexes with...
questionsmedicales.fr › Composés chimiques organiques › Complexes de coordination › Ruthenium(II) Diphosphine Complexes with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › ADN topoisomérases de type I › Ruthenium(II) Diphosphine Complexes with...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › Ruthenium(II) Diphosphine Complexes with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Ruthenium(II) Diphosphine Complexes with...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Ruthenium(II) Diphosphine Complexes with...
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Phosphines › Ruthenium(II) Diphosphine Complexes with...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Ruthénium › Ruthenium(II) Diphosphine Complexes with...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Inhibiteurs des topoisomérases › Inhibiteurs de la topoisomérase-I › Ruthenium(II) Diphosphine Complexes with...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Ruthenium(II) Diphosphine Complexes with...