Hydrogen sulfide-dependent microvascular vasodilation is improved following chronic sulfhydryl-donating antihypertensive pharmacotherapy in adults with hypertension.

Aged Angiotensin-Converting Enzyme Inhibitors / metabolism Antihypertensive Agents / metabolism Blood Pressure / drug effects Captopril / metabolism Female Humans Hydrogen Sulfide / metabolism Hypertension / diagnosis Male Microcirculation / drug effects Middle Aged Nitric Oxide / metabolism Proof of Concept Study Prospective Studies Skin / blood supply Time Factors Treatment Outcome Vasodilation / drug effects
blood pressure endothelium-dependent dilation hydrogen sulfide intradermal microdialysis nitric oxide-dependent dilation

Journal

American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228

Informations de publication

Date de publication:
01 10 2021
Historique:
pubmed: 4 9 2021
medline: 26 10 2021
entrez: 3 9 2021
Statut: ppublish

Résumé

Hypertension is characterized by systemic microvascular endothelial dysfunction, in part due to a functional absence of hydrogen sulfide (H

Identifiants

DOI: 10.1152/ajpheart.00404.2021 PMID: 34477463 PMC: PMC8803310
pubmed: 34477463
doi: 10.1152/ajpheart.00404.2021
pmc: PMC8803310
doi:

Substances chimiques

Angiotensin-Converting Enzyme Inhibitors 0
Antihypertensive Agents 0
Nitric Oxide 31C4KY9ESH
Captopril 9G64RSX1XD
Hydrogen Sulfide YY9FVM7NSN

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

H728-H734

Subventions

Organisme : NHLBI NIH HHS
ID : R00 HL133414
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH123928
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG049676
Pays : United States
Organisme : HHS | National Institutes of Health (NIH)
ID : NIH T-32-5T32AG049676
Organisme : HHS | National Institutes of Health (NIH)
ID : NIH HL093238
Organisme : NHLBI NIH HHS
ID : R01 HL093238
Pays : United States

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Auteurs

Gabrielle A Dillon (GA)

Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania.
Center for Healthy Aging, The Pennsylvania State University, University Park, Pennsylvania.
ORCID: 0000-0001-5365-2852

Anna E Stanhewicz (AE)

Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania.
Department of Health and Human Physiology, The University of Iowa, Iowa City, Iowa.

Corinna Serviente (C)

Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania.
Center for Healthy Aging, The Pennsylvania State University, University Park, Pennsylvania.
Institute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, Massachusetts.
Department of Kinesiology, University of Massachusetts Amherst, Amherst, Massachusetts.

Jody L Greaney (JL)

Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania.
Department of Kinesiology, University of Texas Arlington, Arlington, Texas.

Lacy M Alexander (LM)

Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania.
Center for Healthy Aging, The Pennsylvania State University, University Park, Pennsylvania.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Hydrogen sulfide-dependent microvascular...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéases › Inhibiteurs de l'enzyme de conversion de l'angiotensine › Hydrogen sulfide-dependent microvascular...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Antihypertenseurs › Hydrogen sulfide-dependent microvascular...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Pression sanguine › Hydrogen sulfide-dependent microvascular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés cycliques › Imino-acides › Proline › Captopril › Hydrogen sulfide-dependent microvascular...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Hydrogen sulfide-dependent microvascular...
questionsmedicales.fr › Produits chimiques inorganiques › Sulfure d'hydrogène › Hydrogen sulfide-dependent microvascular...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypertension artérielle › Hydrogen sulfide-dependent microvascular...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Circulation sanguine › Microcirculation › Hydrogen sulfide-dependent microvascular...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Hydrogen sulfide-dependent microvascular...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Hydrogen sulfide-dependent microvascular...
questionsmedicales.fr › Disciplines des sciences naturelles › Science › Recherche › Étude de validation de principe › Hydrogen sulfide-dependent microvascular...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Hydrogen sulfide-dependent microvascular...
questionsmedicales.fr › Système tégumentaire › Peau › Hydrogen sulfide-dependent microvascular...
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › Hydrogen sulfide-dependent microvascular...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Hydrogen sulfide-dependent microvascular...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Vasodilatation › Hydrogen sulfide-dependent microvascular...