T follicular helper cells: Their development and importance in the context of helminthiasis.
Cell differentiation
Cell surface molecules
Cell surface receptors
Parasitic-Helminth infections
Journal
Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
05
06
2021
revised:
25
08
2021
accepted:
28
08
2021
pubmed:
4
9
2021
medline:
10
11
2021
entrez:
3
9
2021
Statut:
ppublish
Résumé
The development of T follicular helper cells (Tfh) is a multifactorial process that occurs in multiple stages. After their activation the Tfh cells interact with the B cells to complete their differentiation. During this process, the Tfh cells begin to express canonical molecules such as the transcription factor B-cell lymphoma 6 protein, the CXC chemokine receptors type 5, and the inducible T-cell costimulator, as well as secreting other molecules such as IL-21. This whole process is regulated positively and negatively by several factors so that the best response is offered in the face of diseases of various origins, among them helminthiasis. In this context, the role of circulating Tfh, IL-4 and IgG subtypes is essential for an effective response against these pathogens. In this review, the migration process and the differentiation of Tfh, the regulation, their cell subtypes and the role of Tfh in the context of helminth infections will be addressed.
Identifiants
pubmed: 34478881
pii: S1521-6616(21)00181-9
doi: 10.1016/j.clim.2021.108844
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
108844Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.