Notch signaling in reproduction.
Notch signaling
gynecological disease
reproduction
Journal
Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
28
06
2021
revised:
27
07
2021
accepted:
06
08
2021
pubmed:
5
9
2021
medline:
23
4
2022
entrez:
4
9
2021
Statut:
ppublish
Résumé
The Notch signaling pathway is conserved among mammalian species and controls proliferation, differentiation, and cell death in many organs throughout the body including the reproductive tract. Notch signaling plays critical roles in the development and function of both the male and female reproductive systems. Specifically, within the female reproductive tract, Notch signaling is hormone regulated and mediates key reproductive events important for ovarian and uterine function. In this review, we highlight the tissues that express Notch receptors, ligands, and downstream effectors and distinguish how these molecules regulate reproductive function in male and female mice, non-human primates, and humans. Finally, we describe some of the aberrations in Notch signaling in female reproductive pathologies and identify opportunities for future investigation.
Identifiants
pubmed: 34479767
pii: S1043-2760(21)00182-X
doi: 10.1016/j.tem.2021.08.002
pmc: PMC8585702
mid: NIHMS1733074
pii:
doi:
Substances chimiques
Receptors, Notch
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1044-1057Subventions
Organisme : NICHD NIH HHS
ID : R01 HD042280
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD099090
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD087166
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104940
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests to declare.
Références
Endocrinology. 2019 Dec 1;160(12):2863-2876
pubmed: 31609444
FASEB J. 2012 Jan;26(1):282-94
pubmed: 21990372
Nature. 2000 Jul 27;406(6794):369-75
pubmed: 10935626
Reprod Sci. 2021 May;28(5):1353-1361
pubmed: 33067753
Reprod Biol Endocrinol. 2004 Jun 16;2:34
pubmed: 15200677
Mol Endocrinol. 2014 Apr;28(4):499-511
pubmed: 24552588
Lancet. 2010 Aug 21;376(9741):631-44
pubmed: 20598363
PLoS One. 2014 Nov 20;9(11):e113365
pubmed: 25412258
Endocrinology. 2012 Jun;153(6):2884-96
pubmed: 22535768
Reproduction. 2017 Jun;153(6):R187-R204
pubmed: 28283672
EBioMedicine. 2019 Jun;44:563-573
pubmed: 31201143
PLoS One. 2013 Aug 28;8(8):e72767
pubmed: 24015274
Nat Med. 2012 Dec;18(12):1754-67
pubmed: 23223073
FASEB J. 2018 May;32(5):2452-2466
pubmed: 29242273
Endocrinology. 2006 Aug;147(8):3870-6
pubmed: 16690806
Int J Mol Sci. 2020 Mar 13;21(6):
pubmed: 32183093
Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2300-5
pubmed: 26858409
J Anat. 2008 Oct;213(4):464-72
pubmed: 18691378
Nat Rev Endocrinol. 2018 May;14(5):270-284
pubmed: 29569621
Mol Biol Evol. 2016 Dec;33(12):3161-3169
pubmed: 27634871
Lancet. 2004 Nov 13-19;364(9447):1789-99
pubmed: 15541453
Biol Reprod. 2021 Mar 11;104(3):539-547
pubmed: 33284968
Cell Res. 2014 Aug;24(8):925-42
pubmed: 24971735
Cold Spring Harb Perspect Biol. 2012 Oct 01;4(10):
pubmed: 23028119
Adv Anat Embryol Cell Biol. 2015;216:189-213
pubmed: 26450500
Oncogene. 2010 Jan 14;29(2):201-13
pubmed: 19838210
Iran J Basic Med Sci. 2019 Apr;22(4):426-431
pubmed: 31168348
Oncol Rep. 2012 Feb;27(2):504-10
pubmed: 22075757
Cell Tissue Res. 2007 Dec;330(3):527-34
pubmed: 17955263
J Androl. 2001 Nov-Dec;22(6):999-1011
pubmed: 11700865
J Cancer. 2019 Jun 2;10(13):3028-3036
pubmed: 31281480
Dev Biol. 2006 Dec 15;300(2):497-511
pubmed: 17046738
Andrology. 2016 Mar;4(2):314-27
pubmed: 26825631
Annu Rev Pathol. 2017 Jan 24;12:245-275
pubmed: 27959635
Cell Death Differ. 2020 Apr;27(4):1341-1354
pubmed: 31527799
J Endocr Soc. 2018 May 25;2(7):765-778
pubmed: 30151432
Mol Neurobiol. 2002 Aug;26(1):81-95
pubmed: 12392058
Nat Rev Genet. 2020 Jan;21(1):27-43
pubmed: 31534202
Cell. 2009 Apr 17;137(2):216-33
pubmed: 19379690
Reprod Biol Endocrinol. 2015 Aug 26;13:96
pubmed: 26307032
EMBO Rep. 2019 May;20(5):
pubmed: 30914409
Biol Reprod. 2005 Oct;73(4):833-9
pubmed: 15987820
Angiogenesis. 2018 Feb;21(1):37-46
pubmed: 28993956
Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2543-8
pubmed: 10051679
Reprod Sci. 2019 Jun;26(6):774-784
pubmed: 30213224
Cell Death Dis. 2019 Jun 5;10(6):438
pubmed: 31165749
Reproduction. 2014 Feb 04;147(3):R75-86
pubmed: 24357662
Adv Enzyme Regul. 2009;49(1):134-41
pubmed: 19344631
PLoS One. 2019 Dec 20;14(12):e0226570
pubmed: 31860685
J Clin Endocrinol Metab. 2015 Mar;100(3):E433-42
pubmed: 25546156
Endocrinology. 2018 Jan 1;159(1):184-198
pubmed: 29126263
Hum Reprod. 2016 Jul;31(7):1552-61
pubmed: 27122490
Placenta. 2017 Aug;56:65-72
pubmed: 28117145
Curr Top Dev Biol. 2010;92:73-129
pubmed: 20816393
J Clin Endocrinol Metab. 2020 May 1;105(5):
pubmed: 32119078
Reprod Biomed Online. 2003 Sep;7(2):151-61
pubmed: 14567882
Clin Cancer Res. 2006 Feb 15;12(4):1074-9
pubmed: 16489059
J Mol Histol. 2014 Dec;45(6):697-706
pubmed: 25034535
PLoS One. 2013 Aug 13;8(8):e71440
pubmed: 23967210
Cell Tissue Res. 2016 Jul;365(1):197-208
pubmed: 26899251
Hum Reprod. 2013 May;28(5):1161-71
pubmed: 23477906
Int J Mol Sci. 2018 Aug 21;19(9):
pubmed: 30134622
Semin Cell Dev Biol. 2020 Sep;105:86-101
pubmed: 32423851
Reprod Fertil Dev. 2015 May 05;:
pubmed: 25940784
EMBO Rep. 2019 Jul;20(7):e46436
pubmed: 31267714
Int J Oncol. 2000 Dec;17(6):1131-9
pubmed: 11078798
PLoS One. 2014 Nov 14;9(11):e112723
pubmed: 25397403
Adv Exp Med Biol. 2020;1227:9-27
pubmed: 32072496
Mol Hum Reprod. 2017 Jul 1;23(7):488-499
pubmed: 28486700
Vasc Cell. 2015 Dec 01;7:9
pubmed: 26629328
Placenta. 2017 Jul;55:5-12
pubmed: 28623973
Int J Mol Sci. 2020 Sep 05;21(18):
pubmed: 32899448
Development. 2011 Jul;138(14):2987-98
pubmed: 21693515
Geburtshilfe Frauenheilkd. 2013 Sep;73(9):924-931
pubmed: 24771944
Adv Exp Med Biol. 2021;1287:47-57
pubmed: 33034025