NDK/NME proteins: a host-pathogen interface perspective towards therapeutics.
Leishmania
Mycobacterium
NDK
NME
Non-metastatic enzyme
Nucleoside diphosphate kinase
Journal
Current genetics
ISSN: 1432-0983
Titre abrégé: Curr Genet
Pays: United States
ID NLM: 8004904
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
20
02
2021
accepted:
19
06
2021
revised:
18
06
2021
pubmed:
5
9
2021
medline:
17
3
2022
entrez:
4
9
2021
Statut:
ppublish
Résumé
No effective vaccine is available for any parasitic disease. The treatment to those is solely dependent on chemotherapy, which is always threatened due to development of drug resistance in bugs. This warrants identification of new drug targets. Here, we discuss Nucleoside diphosphate kinases (NDKs) of pathogens that alter host's intra and extracellular environment, as novel drug targets to simultaneously tackle multiple pathogens. NDKs having diverse functions, are highly conserved among prokaryotes and eukaryotes (the mammal NDKs are called NMEs [non-metastatic enzymes]). However, NDKs and NMEs have been separately analysed in the past for their structure and functions. The role of NDKs of pathogen in modulation of inflammation, phagocytosis, apoptosis, and ROS generation in host is known. Conversely, its combined contribution in host-pathogen interaction has not been studied yet. Through the sequence and domain analysis, we found that NDKs can be classified in two groups. One group comprised NMEs 1-4 and few NDKs of select essential protozoan parasites and the bacterium Mycobacterium tuberculosis. The other group included NME7 and the other NDKs of those parasites, posing challenges in the development of drugs specifically targeting pathogen NDKs, without affecting NME7. However, common drugs targeting group 2 NDKs of pathogens can be designed, as NME7 of group 2 is expressed only in ciliated host cells. This review thus analyses comparatively for the first time the structures and functions of human NMEs and pathogen NDKs and predicts the possibilities of NDKs as drug targets. In addition, pathogen NDKs have been now provided a nomenclature in alignment with the NMEs of humans.
Identifiants
pubmed: 34480234
doi: 10.1007/s00294-021-01198-9
pii: 10.1007/s00294-021-01198-9
doi:
Substances chimiques
Nucleoside-Diphosphate Kinase
EC 2.7.4.6
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
15-25Subventions
Organisme : Department of Biotechnology , Ministry of Science and Technology
ID : BT/PR13073/MED/29/923/2015
Organisme : UGC-DAE Consortium for Scientific Research, University Grants Commission
ID : 325245
Organisme : Science and Engineering Research Board
ID : EMR/2015/000874
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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