Roles of microglia in Alzheimer's disease and impact of new findings on microglial heterogeneity as a target for therapeutic intervention.
Alzheimer’s disease
Heterogeneity
Microglia
Neuroinflammation
Neuroprotection
Single cell resolution
Journal
Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
13
06
2021
revised:
27
08
2021
accepted:
30
08
2021
pubmed:
5
9
2021
medline:
16
11
2021
entrez:
4
9
2021
Statut:
ppublish
Résumé
Microglia are specialized macrophages that reside within the central nervous system and play key roles in brain immunity, development and homeostasis. Recent studies also revealed functions of microglia in neuroprotection and neuroinflammation, leading to the discovery that microglia are involved in several brain pathologies including Alzheimer's disease (AD). However, the beneficial and detrimental actions of this intriguing cell population can be challenging to dissect: the advent of single-cell and single-nucleus transcriptomic technologies has revolutionized our understanding of the heterogeneity of multiple cell types and is now being applied to the study of microglia in health and disease. Here, we review recent findings on microglial biology, focusing on insights from single cell transcriptomic studies and the heterogeneity that they reveal, and consider the impact of these findings on our understanding of AD. We also discuss how microglia might represent a next-generation therapeutic target for treatment of AD and other neuroinflammatory conditions.
Identifiants
pubmed: 34480881
pii: S0006-2952(21)00370-1
doi: 10.1016/j.bcp.2021.114754
pii:
doi:
Substances chimiques
Neuroprotective Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
114754Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.