Merkel Cell Polyomavirus‒Negative Merkel Cell Carcinoma Originating from In Situ Squamous Cell Carcinoma: A Keratinocytic Tumor with Neuroendocrine Differentiation.

Carcinoma in Situ Carcinoma, Merkel Cell / genetics Carcinoma, Squamous Cell / genetics Humans Merkel cell polyomavirus / genetics Skin Neoplasms / genetics

Journal

The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720

Informations de publication

Date de publication:
03 2022
Historique:
received: 14 03 2021
revised: 24 06 2021
accepted: 09 07 2021
pubmed: 5 9 2021
medline: 10 5 2022
entrez: 4 9 2021
Statut: ppublish

Résumé

Although virus-negative Merkel cell carcinoma (MCC) is characterized by a high frequency of UV-induced mutations, the expression of two viral oncoproteins is regarded as a key mechanism driving Merkel cell polyomavirus‒positive MCC. The cells in which these molecular events initiate MCC oncogenesis have yet not been identified for both MCC subsets. A considerable proportion of virus-negative MCC is found in association with squamous cell carcinoma (SCC), suggesting (i) coincidental collision, (ii) one providing a niche for the other, or (iii) one evolving from the other. Whole-exome sequencing of four combined tumors consisting of SCC in situ and Merkel cell polyomavirus‒negative MCC showed many mutations shared between SCC and MCC in all cases, indicating a common ancestry and thereby a keratinocytic origin of these MCCs. Moreover, analyses of the combined cases as well as of pure SCC and MCC suggest that RB1 inactivation in SCC facilitates MCC development and that epigenetic changes may contribute to the SCC/MCC transition.

Identifiants

DOI: 10.1016/j.jid.2021.07.175 PMID: 34480892
pubmed: 34480892
pii: S0022-202X(21)02165-5
doi: 10.1016/j.jid.2021.07.175
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

516-527

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Thibault Kervarrec (T)

Department of Pathology, University Hospital Center of Tours, University of Tours, Tours, France; Biologie des infections à polyomavirus team, UMR INRAE ISP 1282, University of Tours, Tours, France; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany. Electronic address: thibaultkervarrec@yahoo.fr.

Silke Appenzeller (S)

Core Unit Bioinformatics, Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Würzburg, Germany.

Mahtab Samimi (M)

Biologie des infections à polyomavirus team, UMR INRAE ISP 1282, University of Tours, Tours, France; Department of Dermatology, University Hospital Center of Tours, University of Tours, Tours, France.

Bhavishya Sarma (B)

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

Eva-Maria Sarosi (EM)

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

Patricia Berthon (P)

Biologie des infections à polyomavirus team, UMR INRAE ISP 1282, University of Tours, Tours, France.

Yannick Le Corre (Y)

Dermatology Department, LUNAM University, University Hospital Center of Angers, Angers, France.

Ewa Hainaut-Wierzbicka (E)

Dermatology Department, University Hospital Center of Poitiers, University of Poitiers, Poitiers, France.

Astrid Blom (A)

Department of General and Oncologic Dermatology, Ambroise-Paré hospital, APHP, Boulogne-Billancourt, France.

Nathalie Benethon (N)

Dermatology Department, Hospital Center of Le Mans, Le Mans, France.

Guido Bens (G)

Dermatology Department, Hospital Center of Orléans, Orléans, France.

Charline Nardin (C)

Dermatology Department, University Hospital Center of Besançon, University of Franche Comté, Besançon, France.

Francois Aubin (F)

Dermatology Department, University Hospital Center of Besançon, University of Franche Comté, Besançon, France.

Monica Dinulescu (M)

Dermatology Department, University Hospital Center of Rennes, Rennes, France; "Institut Dermatologie du Grand Ouest" (IDGO), Nantes, France.

Marie-Laure Jullie (ML)

Department of Pathology, Hôpital Haut-Lévêque, University Hospital Center of Bordeaux, CARADERM network, Pessac, France.

Ágnes Pekár-Lukacs (Á)

Department of Oncology and Pathology, Lund University, Lund, Sweden; Department of Dermatopathology, St John's Institute of Dermatology, St Thomas's Hospital, London, United Kingdom.

Eduardo Calonje (E)

Department of Dermatopathology, St John's Institute of Dermatology, St Thomas's Hospital, London, United Kingdom.

Soumanth Thanguturi (S)

Department of Pathology, University Hospital Center of Tours, University of Tours, Tours, France.

Anne Tallet (A)

Platform of Somatic Tumor Molecular Genetics, University Hospital Center of Tours, Université de Tours, Tours, France.

Marion Wobser (M)

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

Antoine Touzé (A)

Biologie des infections à polyomavirus team, UMR INRAE ISP 1282, University of Tours, Tours, France.

Serge Guyétant (S)

Department of Pathology, University Hospital Center of Tours, University of Tours, Tours, France; Biologie des infections à polyomavirus team, UMR INRAE ISP 1282, University of Tours, Tours, France.

Roland Houben (R)

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

David Schrama (D)

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Épithélioma in situ › Merkel Cell Polyomavirus‒Negative Merkel Cell...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroendocrines › Carcinome neuroendocrine › Carcinome à cellules de Merkel › Merkel Cell Polyomavirus‒Negative Merkel Cell...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs épidermoïdes › Carcinome épidermoïde › Merkel Cell Polyomavirus‒Negative Merkel Cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Merkel Cell Polyomavirus‒Negative Merkel Cell...
questionsmedicales.fr › Virus › Virus oncogènes › Virus tumoraux à ADN › Polyomaviridae › Polyomavirus › Polyomavirus des cellules de Merkel › Merkel Cell Polyomavirus‒Negative Merkel Cell...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Tumeurs cutanées › Merkel Cell Polyomavirus‒Negative Merkel Cell...